Elisabetta Zinellu
University of Sassari
Internal medicineEndocrinologyPathologyGlycosaminoglycanChemistryImmunologyOxidative stressCOPDInflammationDerivatizationHomocysteineIdiopathic pulmonary fibrosisCysteinePathogenesisCapillary electrophoresisIn patientChromatographyGlutathioneApolipoprotein BMedicineGastroenterologyMeta-analysis
64Publications
16H-index
821Citations
Publications 65
Newest
#1Angelo ZinelluH-Index: 31
#2Claudia ColluH-Index: 2
Last. Ciriaco CarruH-Index: 38
view all 13 authors...
Variable patterns of disease progression are typically observed in patients with idiopathic pulmonary fibrosis (IPF). We sought to determine the prognostic capacity of blood cell count indexes, derived from routine complete blood cell (CBC) count, in a cohort of IPF patients. The neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation index (SII), systemic inflammation respo...
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#1Maria Carmina Pau (University of Sassari)H-Index: 3
#2Elisabetta ZinelluH-Index: 16
Last. Pietro Pirina (University of Sassari)H-Index: 26
view all 10 authors...
Oxidative stress induced by nocturnal intermittent hypoxia plays a significant pathophysiological role in obstructive sleep apnea (OSA). Malondialdehyde (MDA), one of the most commonly investigated markers of lipid peroxidation, might assist with the monitoring of oxidative balance in OSA. We conducted a systematic review and meta-analysis to evaluate the differences in circulating MDA concentrations between patients with OSA and non-OSA controls. A systematic search was conducted in the electro...
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#1Alessandro G. FoisH-Index: 17
#2Valentina ScanoH-Index: 4
Last. Angelo ZinelluH-Index: 31
view all 11 authors...
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#1Elisabetta ZinelluH-Index: 16
#2Angelo Zinellu (University of Sassari)H-Index: 31
Last. Pietro Pirina (University of Sassari)H-Index: 26
view all 8 authors...
Background Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease characterized by a not fully reversible airflow limitation associated with an abnormal inflammatory response. Exacerbations of COPD are of major importance in the acceleration of disease progression, in healthcare costs, and negatively affect the patient's quality of life. Exacerbations are characterized by a further increase in the airway inflammation likely driven by oxidative stress. In order to deepen the knowle...
1 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Andrea De Vito (University of Sassari)H-Index: 5
Last. Alessandro G. Fois (University of Sassari)H-Index: 17
view all 14 authors...
Introduction The early identification of factors that predict the length of hospital stay (HS) in patients affected by coronavirus desease (COVID-19) might assist therapeutic decisions and patient flow management. Methodology We collected, at the time of admission, routine clinical, laboratory, and imaging parameters of hypoxia, lung damage, inflammation, and organ dysfunction in a consecutive series of 50 COVID-19 patients admitted to the Respiratory Disease and Infectious Disease Units of the ...
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#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Claudia Collu (University of Sassari)H-Index: 2
Last. Alessandro G. Fois (University of Sassari)H-Index: 17
view all 13 authors...
BACKGROUND While a number of individual patient characteristics are associated with survival in idiopathic pulmonary fibrosis (IPF), their incorporation into combined indexes, such as the GAP index, has been shown to increase the predictive capacity. It is unknown whether the predictive capacity of GAP-derived indexes that also include anthropometric and exercise parameters is superior to the original instrument. METHODS We tested the four-year survival predictive capacity of a modified, adimens...
1 CitationsSource
#1Elisabetta ZinelluH-Index: 16
#2Alessandro G. FoisH-Index: 17
Last. Pietro PirinaH-Index: 26
view all 8 authors...
Background: Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by chronic airway inflammation and lung parenchyma damage. Systemic inflammation and oxidative stress also play a role in the pathogenesis of COPD. Serum albumin is a negative acute-phase protein with antioxidant effects and an important marker of malnutrition. The aim of this meta-analysis was to investigate differences in serum albumin concentrations between patients with stable COPD and non-COPD ...
1 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Francesco Arru (University of Sassari)H-Index: 1
Last. Alessandro G. Fois (University of Sassari)H-Index: 17
view all 14 authors...
Increased concentrations of serum aspartate transaminase (AST) and alanine transaminase (ALT) are common in COVID-19 patients. However, their capacity to predict mortality, particularly the AST/ALT ratio, commonly referred to as the De Ritis ratio, is unknown. We investigated the association between the De Ritis ratio on admission and in-hospital mortality in 105 consecutive patients with coronavirus disease of 2019 (COVID-19) admitted to three COVID-19 referral centres in Sardinia, Italy. The D...
13 CitationsSource
#1Alessandro G. FoisH-Index: 17
Last. Angelo ZinelluH-Index: 31
view all 15 authors...
Background The rapid onset of a systemic pro-inflammatory state followed by acute respiratory distress syndrome is the leading cause of mortality in patients with COVID-19. We performed a retrospective observational study to explore the capacity of different complete blood cell count (CBC)-derived inflammation indexes to predict in-hospital mortality in this group. Methods The neutrophil to lymphocyte ratio (NLR), derived NLR (dNLR), platelet to lymphocyte ratio (PLR), mean platelet volume to pl...
26 CitationsSource
#1Salvatore Sotgia (University of Sassari)H-Index: 25
#2Panagiotis Paliogiannis (University of Sassari)H-Index: 19
Last. Angelo Zinellu (University of Sassari)H-Index: 31
view all 10 authors...
The aim of this systematic review and meta-analysis was to assess the blood concentrations of the total and reduced forms of the low-molecular-weight antioxidant thiol glutathione (GSH) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. A literature search was conducted in the PubMed and Web of Science databases from inception until June 2020. In the 18 studies identified (involving a total of 974 COPD patients and 631 healthy controls), the pooled red...
2 CitationsSource