Mediastinal fibrosis and mirtazapin

Published on May 28, 2011in Revue de Médecine Interne0.783
· DOI :10.1016/J.REVMED.2010.08.012
A. Akalay1
Estimated H-index: 1
,
M. Ost1
Estimated H-index: 1
,
B. Hanson1
Estimated H-index: 1
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Abstract
We report a 61-year-old woman who developed a superior vena cava syndrome due to mediastinal fibrosis. This mediastinal fibrosis resolved after the discontinuation of a chronic treatment by mirtazapin that the patient was receiving for the previous six years, suggesting a role of this treatment in the genesis of the mediastinal fibrosis.
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#1Tamar Giorgadze (Cornell University)H-Index: 14
#2June Koizumi (Cornell University)H-Index: 13
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Abstract Sclerosing mediastinitis (SM) is an aggressive fibroproliferative process in the mediastinum that may lead to encasement of mediastinal structures within a dense fibrotic mass. This disease may cause significant clinical complications, morbidity, and even mortality. The etiology and pathogenesis of SM is unclear and in more than one third of cases remains idiopathic. Among the known causes of SM, granulomatous infection is the commonest. Association of SM with radiation therapy has been...
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