Follicular regulatory helper T cells control the response of regulatory B cells to a high-cholesterol diet

Aims B cell functions in the process of atherogenesis have been investigated but several aspects remain to be clarified. Methods and results In this study, we show that follicular regulatory helper T cells (TFR) control regulatory B cell (BREG) populations in Apoe−/− mice models on a high-cholesterol diet (HCD). Feeding mice with HCD resulted in up-regulation of TFR and BREG cell populations, causing the suppression of proatherogenic follicular...