Original paper
TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
Abstract
The tripartite-motif protein, TRIM5α, is an innate immune sensor that potently restricts retrovirus infection by binding to human immunodeficiency virus capsids. Higher-ordered oligomerization of this protein forms hexagonally patterned structures that wrap around the viral capsid, despite an anomalously low affinity for the capsid protein (CA). Several studies suggest TRIM5α oligomerizes into a lattice with a symmetry and spacing that matches...
Paper Details
Title
TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
Published Date
Mar 11, 2020
Journal
Volume
11
Issue
1