Aortic Stiffness and White Matter Microstructural Integrity Assessed by Diffusion Tensor Imaging: The ARIC-NCS.

Published on Mar 17, 2020in Journal of the American Heart Association4.605
· DOI :10.1161/JAHA.119.014868
Jingkai Wei14
Estimated H-index: 14
(UNC: University of North Carolina at Chapel Hill),
Priya Palta5
Estimated H-index: 5
(Columbia University)
+ 12 AuthorsGerardo Heiss141
Estimated H-index: 141
(UNC: University of North Carolina at Chapel Hill)
Sources
Abstract
Background Changes in white matter microstructural integrity are detectable before appearance of white matter lesions on magnetic resonance imaging as a manifestation of cerebral small‐vessel disea...
📖 Papers frequently viewed together
20095.90NeuroImage
10 Authors (Herve Lemaitre, ..., V S Mattay)
2019
1 Citations
References44
Newest
#1Priya Palta (UNC: University of North Carolina at Chapel Hill)H-Index: 18
#2A. Richey Sharrett (Johns Hopkins University)H-Index: 105
Last. Gerardo Heiss (UNC: University of North Carolina at Chapel Hill)H-Index: 141
view all 14 authors...
Background Central arterial stiffening and increased pulsatility, with consequent cerebral hypoperfusion, may result in structural brain damage and cognitive impairment. Methods and Results We anal...
15 CitationsSource
#1Anna Kucharska-Newton (UNC: University of North Carolina at Chapel Hill)H-Index: 24
#2Lee Stoner (UNC: University of North Carolina at Chapel Hill)H-Index: 27
Last. Michelle L. Meyer (UNC: University of North Carolina at Chapel Hill)H-Index: 12
view all 3 authors...
Background: Vascular age is an emerging health indicator and predictor of end-organ damage to the heart, brain, and kidney. Although there have been many review publications concerning risk factors for vascular aging, most include cross-sectional epidemiological studies, limiting inferences about temporality. There is a need for a review of longitudinal epidemiological studies with repeated measures of vascular structure and function to allow for a systematic examination of determinants of vascu...
17 CitationsSource
#1Daniel Bos (Harvard University)H-Index: 25
#2Frank J. Wolters (Harvard University)H-Index: 23
Last. Albert Hofman (Harvard University)H-Index: 290
view all 7 authors...
Abstract Introduction Cerebral small vessel disease is increasingly linked to dementia. Methods We systematically searched Medline, Embase, and Cochrane databases for prospective population-based studies addressing associations of white matter hyperintensities, covert brain infarcts (i.e., clinically silent infarcts), and cerebral microbleeds with risk of all-dementia or Alzheimer's disease and performed meta-analyses. Results We identified 11 studies on white matter hyperintensities, covert bra...
37 CitationsSource
#1Lisanne Tap (EUR: Erasmus University Rotterdam)H-Index: 5
#2Annegreet van Opbroek (EUR: Erasmus University Rotterdam)H-Index: 7
Last. Francesco U.S. Mattace-Raso (EUR: Erasmus University Rotterdam)H-Index: 37
view all 5 authors...
markdownabstract__Purpose:__ Cerebral white matter lesions (WML) and brain atrophy are frequent in older persons and are associated with adverse outcomes. It has been suggested that aortic stiffness plays a role in the pathogenesis of WML and gray matter (GM) loss. There is, however, little evidence on the association between aortic stiffness and brain integrity in older patients. In this study, we investigated whether aortic stiffness is associated with WML and GM volume in older patients with ...
4 CitationsSource
#1Kenzo Koizumi (Cornell University)H-Index: 7
#2Yorito Hattori (Cornell University)H-Index: 3
Last. Constantino Iadecola (Cornell University)H-Index: 4
view all 14 authors...
The ApoE4 allele is associated with increased risk of small vessel disease, which is a cause of vascular cognitive impairment. Here, we report that mice with targeted replacement (TR) of the ApoE gene with human ApoE4 have reduced neocortical cerebral blood flow compared to ApoE3-TR mice, an effect due to reduced vascular density rather than slowing of microvascular red blood cell flow. Furthermore, homeostatic mechanisms matching local delivery of blood flow to brain activity are impaired in Ap...
42 CitationsSource
#1Keenan A. Walker (Johns Hopkins University)H-Index: 12
#2Melinda C. Power (Johns Hopkins University)H-Index: 27
Last. Rebecca F. Gottesman (Johns Hopkins University)H-Index: 72
view all 10 authors...
Background and Purpose— It is currently unclear whether midlife systemic inflammation promotes the development of white matter (WM) abnormalities and small vessel disease in the elderly. We examined the association of midlife systemic inflammation with late-life WM hyperintensity volume, deep and periventricular WM microstructural integrity (fractional anisotropy and mean diffusivity [MD]), cerebral infarcts, and microbleeds in a biracial prospective cohort study. Methods— Linear and logistic re...
44 CitationsSource
#1Andrea L.C. Schneider (Johns Hopkins University)H-Index: 31
#2Elizabeth Selvin (Johns Hopkins University)H-Index: 86
Last. Rebecca F. Gottesman (Johns Hopkins University)H-Index: 72
view all 9 authors...
OBJECTIVE To examine the associations of prediabetes, diabetes, and diabetes severity (as assessed by HbA1c and diabetes duration) with brain volumes and vascular pathology on brain MRI and to assess whether the associations of diabetes with brain volumes are mediated by brain vascular pathology. RESEARCH DESIGN AND METHODS Cross-sectional study of 1,713 participants in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS) (mean age 75 years, 60% female, 27% black, 30% prediabe...
39 CitationsSource
#1Pauline Maillard (UC Davis: University of California, Davis)H-Index: 30
#2Gary F. MitchellH-Index: 71
Last. Charles DeCarli (UC Davis: University of California, Davis)H-Index: 137
view all 11 authors...
Background and Purpose— Previous reports from the Framingham Heart Study have identified cross-sectional associations of arterial stiffness, as reflected by carotid–femoral pulse wave velocity (CFPWV) and systolic blood pressure with vascular brain injury. The purpose of this study is to examine free water (FW), fractional anisotropy (FA), and white matter hyperintensities (WMH) in relation to arterial stiffness among subjects of the Framingham Offspring and Third-Generation cohorts. Methods— In...
39 CitationsSource
#1Melinda C. Power (GW: George Washington University)H-Index: 27
#2Jonathan V. Tingle (UMMC: University of Mississippi Medical Center)H-Index: 4
Last. Thomas H. Mosley (University of Mississippi)H-Index: 95
view all 12 authors...
BackgroundDiffusion tensor imaging measures of white matter (WM) microstructural integrity appear to provide earlier indication of WM injury than WM hyperintensities; however, risk factors for poor...
32 CitationsSource
#1Sikarin Upala (MU: Mahidol University)H-Index: 16
#1Sikarin Upala (MU: Mahidol University)H-Index: 22
Last. Anawin Sanguankeo (MU: Mahidol University)H-Index: 23
view all 4 authors...
Abstract Background Arterial stiffness has been observed to be an independent predictor for cardiovascular events. Effects of cholesterol lowering agents (statins) on arterial stiffness are inconsistent. We conducted a systematic review with a meta-analysis of all RCTs investigating the impact of statin therapy on arterial properties. Methods We comprehensively searched the databases of MEDLINE, EMBASE, and Cochrane from their dates of inception through April 2016. The inclusion criteria were pu...
35 CitationsSource
Cited By3
Newest
Aortic stiffness increases markedly with age and is associated with excess risk for various adverse clinical outcomes, including heart disease, dementia, and kidney disease. Although evidence for adverse effects of aortic stiffening is overwhelming, integration of direct and indirect measures of aortic stiffness into routine clinical assessment has lagged behind the science. This brief review will examine recent evidence supporting the value of stiffness as an important new risk factor for hyper...
Source
#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 6 authors...
Midlife vascular disease increases risk for dementia and effects of vascular dysfunction on brain health differ between men and women. Elevated pulse pressure, a surrogate for arterial stiffness, contributes to cerebrovascular pathology and white matter damage that may advance cognitive aging; however, it remains unclear how associations between pulse pressure and neural integrity differ by sex and age. This study used restriction spectrum imaging to examine associations between pulse pressure a...
Source
#1Nick Winder (UO: University of Oregon)H-Index: 1
#2Emily Reeve (UO: University of Oregon)H-Index: 1
Last. Ashley E. Walker (UO: University of Oregon)H-Index: 22
view all 3 authors...
There are no effective treatments available to halt or reverse the progression of age-related cognitive decline and Alzheimer's disease. Thus, there is an urgent need to understand the underlying m...
Source