Mechanism-based integrated assay systems for the prediction of drug-induced liver injury
Abstract
Drug-induced liver injury (DILI) can cause hepatic failure and result in drug withdrawal from the market. It has host-related and compound-dependent mechanisms. Preclinical prediction of DILI risk is very challenging and safety assessments based on animals inadequately forecast human DILI risk. In contrast, human-derived in vitro cell culture-based models could improve DILI risk prediction accuracy. Here, we developed and validated an innovative...
Paper Details
Title
Mechanism-based integrated assay systems for the prediction of drug-induced liver injury
Published Date
May 1, 2020
Volume
394
Pages
114958 - 114958
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