Toxicology and Applied Pharmacology
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#1Tian Y (JLU: Jilin University)H-Index: 1
#2Zhenyu Wang (JLU: Jilin University)H-Index: 2
Last. Yuguang Zhao (JLU: Jilin University)H-Index: 12
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Abstract null null Diabetic cardiomyopathy (DCM) is a serious diabetic complication that lacks effective preventive or therapeutic approaches. Wild-type and Klf15 knockout (Klf15-KO) mice were fed with either high fat diet (HFD, 60% kcal from fat) or normal diet (ND, 10% kcal from fat) for 3 months and then injected with streptozotocin or vehicle, to induce type 2 diabetes (T2D). All T2D and age-matched control mice were treated with or without SDF-1β at 5 mg/kg body-weight twice a week and also...
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#1Michael Hubert Wrobel (PAN: Polish Academy of Sciences)H-Index: 3
#2J. Mlynarczuk (PAN: Polish Academy of Sciences)H-Index: 12
Abstract null null Dichlorodiphenyltrichloroethane (DDT) is a representative organochlorine insecticide and a known endocrine disruptor. Malathion is an organophosphate insecticide and a next-generation pesticide. Previously, it was shown that oxytocin (OT) and prostaglandins (PGs) are involved in the mechanism of the adverse effect of DDT on bovine myometrial contractions. However, disruption of myometrial contractions without disruption of cervical activity may not be sufficient to cause prete...
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#1Guojun Zhang (PRC: China Medical University (PRC))
#2Mingkai Xu (CAS: Chinese Academy of Sciences)H-Index: 8
Last. Huiwen Zhang (CAS: Chinese Academy of Sciences)H-Index: 15
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Abstract null null Bacterial superantigens potently activate conventional T-cells to induce massive cytokine production and mediate tumor cell death. To engineer superantigens for immunotherapy against tumors in clinic, we previously generated SAM-1, a staphylococcal enterotoxins C2 (SEC2) mutant, that exhibited significantly reduced toxicity but maintained the superantigen activity in animal models. This present study aimed to investigate whether SAM-1 activates T cells and induces apoptosis in...
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#1Mingming LiH-Index: 5
#2Xiaomeng SunH-Index: 1
Last. Hua WeiH-Index: 1
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Abstract null null Colorectal cancer (CRC) remains a major concern with high morbidity and mortality worldwide. Despite the positive influence of chemotherapy on the decline in CRC mortality, the negative influence of chemotherapy-related adverse effects (CRAEs) caused by capecitabine (Cap) remains a challenging problem. DNA methylation alteration plays a pivotal role in gene expression regulation. Here, we aimed to screen reliable and novel biomarkers for CRC diagnosis and CRAE prediction using...
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#1Wing Y. Tuet (DA: United States Department of the Army)H-Index: 1
#2Samuel A. Pierce (DA: United States Department of the Army)H-Index: 1
Last. Benjamin Wong (DA: United States Department of the Army)H-Index: 6
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Abstract null null Exposure to phosphine (PH3) presents with a host of diverse, non-specific symptoms that span multiple organ systems and is characterized by a high mortality rate. While a comprehensive mechanism for PH3 poisoning remains inconclusive, prior studies have implicated cardiac failure and circulatory compromise as potential pathways central to PH3-induced mortality. In this study, milrinone (MLR), a phosphodiesterase-3 inhibitor used to treat cardiac failure, was investigated as a ...
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#1Weixing Xu (PKU: Peking University)
#2Yuze Qi (PKU: Peking University)
Last. Jing Huang (PKU: Peking University)H-Index: 53
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Abstract null null Background null Previous work indicated that benzo[a]pyrene (B(a)P) exposure in utero might adversely affect neurodevelopment and cause Parkinson's Disease (PD)-like symptoms. However, the effect of utero exposure to B(a)P on PD-like α-synucleinopathy and the mechanism under are unclear. null null null Objective null The A53T human alpha-synuclein (α-syn) transgenic mice (M83+/−) were used in this study to gain insights into the role of B(a)P exposure in utero in the onset of ...
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#1Paige C. Mundy (UC Davis: University of California, Davis)H-Index: 3
#2Brandon Pressly (UC Davis: University of California, Davis)H-Index: 5
Last. Pamela J. Lein (UC Davis: University of California, Davis)H-Index: 58
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Abstract null null The chemical threat agent tetramethylenedisulfotetramine (TETS) is a γ-aminobutyric acid type A receptor (GABA AR) antagonist that causes life threatening seizures. Currently, there is no specific antidote for TETS intoxication. TETS-induced seizures are typically treated with benzodiazepines, which function as nonselective positive allosteric modulators (PAMs) of synaptic GABAARs. The major target of TETS was recently identified as the GABAAR α2β3γ2 subtype in electrophysiolo...
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#1Ana Olívia Martins Laurentino (UFRGS: Universidade Federal do Rio Grande do Sul)
#2Janaína Solómon (UFRGS: Universidade Federal do Rio Grande do Sul)
Last. Solange Cristina Garcia (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 37
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Abstract null null The use of the anthelmintic levamisole as a cocaine adulterant has been increasing worldwide. Complications caused by this association include systemic vasculitis, agranulocytosis, neutropenia, tissue necrosis, pulmonary hemorrhage, and renal injury. Data about toxicity of levamisole are scarce, therefore the aim of this study was to evaluate the acute and subchronic toxic effects of levamisole in rats. Male Wistar rats received saline or levamisole by intraperitoneal route at...
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#1L. Jin (University of Louisville)H-Index: 1
#1Lexiao Jin (AHA: American Heart Association)H-Index: 4
Last. Daniel J. ConklinH-Index: 38
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Acrolein, an electrophilic α,β-unsaturated aldehyde, is present in foods and beverages, and is a product of incomplete combustion, and thus, reaches high ppm levels in tobacco smoke and structural fires. Exposure to acrolein is linked with cardiopulmonary toxicity and cardiovascular disease risk. The hypothesis of this study is the direct effects of acrolein in isolated murine blood vessels (aorta and superior mesenteric artery, SMA) are transient receptor potential ankyrin-1 (TRPA1) dependent. ...
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#1Soledad Solis-Angeles (IPN: Instituto Politécnico Nacional)
#2Cuauhtémoc Arturo Juárez-Pérez (Mexican Social Security Institute)H-Index: 11
Last. Luz M. Del Razo (IPN: Instituto Politécnico Nacional)H-Index: 36
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Abstract null null Background null Some studies in animal models and humans suggest that exposure to lead is associated with hearing loss. Lead can reach the inner ear through the blood circulation; evidence suggests that lead could accumulate in the inner ear, causing inner ear damage. null Aim: To evaluate prestin and otolin-1 protein levels and their relationship with an increased hearing threshold in participants exposed to lead. null null null Methods null We conducted a cross-sectional stu...
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