An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation

Volume: 117, Issue: 12, Pages: 6571 - 6579
Published: Mar 10, 2020
Abstract
MYC controls the transcription of large numbers of long noncoding RNAs (lncRNAs). Since MYC is a ubiquitous oncoprotein, some of these lncRNAs probably play a significant role in cancer. We applied CRISPR interference (CRISPRi) to the identification of MYC-regulated lncRNAs that are required for MYC-driven cell proliferation in the P493-6 and RAMOS human lymphoid cell lines. We identified 320 noncoding loci that play positive roles in cell...
Paper Details
Title
An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation
Published Date
Mar 10, 2020
Volume
117
Issue
12
Pages
6571 - 6579
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