Review paper
Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy
Abstract
To sustain their high proliferation rates, most cancer cells rely on glycolytic metabolism, with production of lactic acid. For many years, lactate was seen as a metabolic waste of glycolytic metabolism; however, recent evidence has revealed new roles of lactate in the tumor microenvironment, either as metabolic fuel or as a signaling molecule. Lactate plays a key role in the different models of metabolic crosstalk proposed in malignant tumors:...
Paper Details
Title
Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy
Published Date
Mar 18, 2020
Journal
Volume
10
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