Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia

Volume: 4, Issue: 3, Pages: 546 - 559
Published: Feb 11, 2020
Abstract
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm accounting for ∼15% of all leukemia. Progress of the disease from an indolent chronic phase to the more aggressive accelerated phase or blast phase (BP) occurs in a minority of cases and is associated with an accumulation of somatic mutations. We performed genetic profiling of 85 samples and transcriptome profiling of 12 samples from 59 CML patients. We identified recurrent somatic...
Paper Details
Title
Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia
Published Date
Feb 11, 2020
Volume
4
Issue
3
Pages
546 - 559
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