Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice

Significance The key molecular mechanisms underlying the etiology of bipolar disorder (BD) have remained enigmatic. As BD patients often show comorbidity with insulin/glucose metabolic syndrome, we hypothesized that the central and peripheral abnormalities might share some identical molecular mechanism. Through investigating the expression of insulin/synapse dual functioning genes in patient induced pluripotent stem cell-derived neurons and...