An interview with Jianwu Dai: understanding the biological processes underlying regeneration to direct the implementation of biomedical materials.

Published on Feb 7, 2020in Biomedical Materials3.174
· DOI :10.1088/1748-605X/AB7389
Myron Spector67
Estimated H-index: 67
(VA Boston Healthcare System)
#1Myron Spector (Brigham and Women's Hospital)H-Index: 67
2 CitationsSource
#1Zhifeng Xiao (CAS: Chinese Academy of Sciences)H-Index: 40
#2Fengwu TangH-Index: 3
Last. Jianwu Dai (CAS: Chinese Academy of Sciences)H-Index: 50
view all 14 authors...
Stem cells and biomaterials transplantation hold a promising treatment for functional recovery in spinal cord injury (SCI) animal models. However, the functional recovery of complete SCI patients was still a huge challenge in clinic. Additionally, there is no clinical standard procedure available to diagnose precisely an acute patient as complete SCI. Here, two acute SCI patients, with injury at thoracic 11 (T11) and cervical 4 (C4) level respectively, were judged as complete injury by a stricte...
29 CitationsSource
#1Hang Lin (CAS: Chinese Academy of Sciences)H-Index: 35
#2Bing Chen (CAS: Chinese Academy of Sciences)H-Index: 19
Last. Jianwu Dai (CAS: Chinese Academy of Sciences)H-Index: 50
view all 6 authors...
Spinal cord injury (SCI) creates an adverse environment for axon regeneration. As a result, the axons at the injury sites begin to be atrophy, retract and lose their functions. Several strategies to promote axon regeneration at the injury site have been tested, but the progress is very limited. One of the major reasons is that the regenerated axons often extend randomly and do not reach the proper place. Fabricating linearly ordered materials as nerve guidance would be important to solve such pr...
68 CitationsSource
Cited By1
#1Myron Spector (Brigham and Women's Hospital)H-Index: 67