Two Mineralocorticoid Receptor–Mediated Mechanisms of Pendrin Activation in Distal Nephrons

Significance Statement Pendrin expressed in renal β -intercalated cells is involved in sodium chloride reabsorption in distal nephron, and plays an essential role in fluid homeostasis and BP control in conjunction with sodium chloride cotransporter in distal convoluted tubules. Using intercalated cell–specific mineralocorticoid receptor knockout mice, the authors found two distinct pathways of pendrin activation: by angiotensin II elevation,...