Bezlotoxumab for the Prevention of Recurrent Clostridioides difficile Infection: 12-Month Observational Data From the Randomized Phase III Trial, MODIFY II.

Published on Aug 14, 2020in Clinical Infectious Diseases9.079
路 DOI :10.1093/CID/CIZ1151
Ellie J. C. Goldstein66
Estimated H-index: 66
Diane M. Citron57
Estimated H-index: 57
+ 5 AuthorsMary Beth Dorr15
Estimated H-index: 15
(MSD: Merck & Co.)
From Monoclonal Antibodies for C. difficile Therapy II, no participants (n = 0/69) with a sustained clinical cure through 12 weeks following bezlotoxumab infusion experienced recurrent Clostridioides difficile infection (rCDI) after 9 months (versus actoxumab + bezlotoxumab, n = 2/65; versus placebo, n = 1/34). Bezlotoxumab's efficacy appears to be due to prevention rather than delayed onset of rCDI. CLINICAL TRIALS REGISTRATION: NCT01513239.
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