#1William A. Werbel(JHUSOM: Johns Hopkins University School of Medicine)H-Index: 9
#2Diane M. Brown(JHUSOM: Johns Hopkins University School of Medicine)H-Index: 7
Last. Jernelle Miller(JHUSOM: Johns Hopkins University School of Medicine)H-Index: 6
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BACKGROUND Organ transplantation from donors with HIV to recipients with HIV (HIV D+/R+) presents risks of donor-derived infections. Understanding clinical, immunologic, and virologic characteristics of HIV+ donors is critical for safety. METHODS We performed a prospective study of donors with HIV-positive and HIV false-positive (FP) testing within the HOPE in Action studies of HIV D+/R+ transplantation (ClinicalTrials.gov NCT02602262; NCT03500315; NCT03734393). We compared clinical characterist...
#1Hualei Xin(Li Ka Shing Faculty of Medicine, University of Hong Kong)
#2Yu Li(CCDC: Chinese Center for Disease Control and Prevention)H-Index: 17
Last. Zhongjie Li(CCDC: Chinese Center for Disease Control and Prevention)H-Index: 25
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Using detailed exposure information on COVID-19 cases, we estimated the mean latent period to be 5.5 days (95% confidence interval: 5.1-5.9 days), shorter than the mean incubation period (6.9 days). Laboratory testing may allow shorter quarantines since 95% of COVID-19 cases shed virus within 10.6 days (95%CI: 9.6-11.6) of infection.
Seven cases of COVID-19 SARS-CoV-2 reinfection from the NBA 2020-2021 occupational testing cohort are described including clinical details, antibody test results, genomic sequencing, and longitudinal RT-PCR results. Reinfections were infrequent and varied in clinical presentation, viral dynamics, and immune response.
The exposure of a research team to chigger mites in southern Chile allowed the first identification of a trombiculid species as vector and reservoir of scrub typhus outside the tsutsugamushi triangle, providing unique insights into the ecology and transmission of this recently discovered rickettsial infection in South America.
#1John Jacob(UH Hilo: University of Hawaii at Hilo)H-Index: 1
#2Argon Steel(UH Hilo: University of Hawaii at Hilo)H-Index: 1
Last. Susan I. Jarvi(UH Hilo: University of Hawaii at Hilo)H-Index: 12
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The safety and efficacy of benzimidazole anthelmintics for the management of rat lungworm disease (neuroangiostrongyliasis) have been questioned regardless of the numerous global experimental animal studies and clinical reports. In this review, 40 of these experimental animal studies and 104 clinical reports are compiled with a focus on albendazole. Among the 144 articles involving an estimated 1034 patients and 2,561 animals, 4.1% were inconclusive or vague regarding the use of benzimidazoles. ...
Last. Heather J. Zar(UCT: University of Cape Town)H-Index: 66
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INTRODUCTION Low vitamin D may increase the risk of tuberculosis; however, previous observational cohort studies have had variable results. We investigated the relationship between vitamin D levels in infancy and subsequent development of tuberculosis throughout childhood. METHODS We enrolled pregnant women between 20-28 weeks' gestation attending antenatal care in a peri-urban South African setting in the Drakenstein Child Health Study. Serum 25(OH)D concentrations were measured in newborn infa...
Last. Steven A. Yukl(SFVAMC: San Francisco VA Medical Center)H-Index: 20
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BACKGROUND Antiretroviral therapy (ART) intensification and disruption of latency have been suggested as strategies to eradicate HIV. ABX464 is a novel antiviral that inhibits HIV RNA biogenesis. We investigated the effect of ABX464 on HIV transcription and total and intact HIV DNA in CD4 + T cells from ART-suppressed participants enrolled in the ABIVAX-005 clinical trial (NCT02990325). METHODS Peripheral CD4 + T cells were available for analysis from nine ART-suppressed participants who were tr...
BACKGROUND Despite microbiological cure, about 50% of TB patients have poor lung recovery. Neutrophils are associated with lung pathology, however, CD16|CD62L-defined subsets have not been studied in TB. Using flow cytometry, we monitored frequencies, phenotype and function of neutrophils following stimulation with Mtb whole cell lysate (WCL) and ESAT-6/CFP-10 fusion protein (EC)) in relation to lung pathology. METHODS Fresh blood from 42 adult, HIV-negative TB patients were analysed pre- and po...