Abstract Chondroitin sulfate (CS) is a naturally derived bioactive macromolecule and the major component of extracellular matrix (ECM), which widely distributed in various organisms and has attracted much attention due to their significant bioactivities. It is regarded as a favorable biomaterial that has been applied extensively in field of drug delivery and tissue engineering due to its property of non-poisonous, biodegradation, biocompatible and as a major component of ECM. The present article reviews the structure and bioactivities of CS, from the preparation to structure analysis, and emphatically focuses on the biomaterial exertion in delivery system and tissue engineering. At the same time, the present application status and prospect of CS are analyzed and the biomaterial exertion of CS in delivery system and various tissue engineering are also comparatively discussed in view of biomaterial development.
Abstract Under the optimal conditions, a crosslinked electrospun polyvinyl alcohol/cinnamon essential oil/β-cyclodextrin (CPVA-CEO-β-CD) nanofibrous films for sustained release of antimicrobials were successfully prepared. Cinnamon essential oil (CEO) can be sustainably released due to CPVA-CEO-β-CD nanofibers complex delivery systems. The chemical crosslinking and physical welding achieved simultaneously by glutaraldehyde atomization fumigation, making fibers more suitable for fresh food packag...
AbstractPolymeric biomaterials play a key role in enhancement of lengthy nerve regeneration and various types of scaffolds were used to pave the way for nerve regeneration. Electrospun fibrous scaf...
Abstract Bladder is affected by numerous pathologies which require augmentation or replacement of the organ. Currently, the gold standard is enterocystoplasty which causes many complications. Bioengineering techniques propose options to overcome these issues. The innovative and very simple tissue engineered three-dimensional spherical bladder model reported here mimics the bladder natural shape using collagen-derived scaffold. Bladder mesenchymal cells were embedded inside the scaffold and epith...
#1Duo Xu(UCLA: University of California, Los Angeles)H-Index: 9
#2Di Wu(UCLA: University of California, Los Angeles)H-Index: 6
Last. Yunfeng Lu(UCLA: University of California, Los Angeles)H-Index: 83
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: The central nervous system (CNS) plays a central role in the control of sensory and motor functions, and the disruption of its barriers can result in severe and debilitating neurological disorders. Neurotrophins are promising therapeutic agents for neural regeneration in the damaged CNS. However, their penetration across the blood-brain barrier remains a formidable challenge, representing a bottleneck for brain and spinal cord therapy. Herein, a nanocapsule-based delivery system is reported th...
Last. Shijie Han(SDU: Shandong University)H-Index: 1
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Abstract We have previously reported that chondroitin sulfate extracted from Sturgeon bone (CSSB) can alleviate the pain caused by osteoarthritis (OA) by reducing the expression of matrix metalloproteinases (MMPs) and inflammatory factors (IL-1, TNF-α and PGE2). However, the mechanism of CSSB for treating OA remains unclear. As is generally accepted, these proteins and factors are regulated by chondrocyte apoptosis in OA. Thus, it is reasonable to hypothesize whether CSSB can inhibit cartilage d...
#2Vivek Veeresh(IMS-BHU: Institute of Medical Sciences, Banaras Hindu University)H-Index: 2
Last. Pradeep Srivastava(IITs: Indian Institutes of Technology)H-Index: 16
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Abstract Chitosan, a natural biopolymer with osteoconductive properties is widely investigated to generate scaffolds for bone tissue engineering applications. However, chitosan based scaffolds lacks in mechanical strength and structural stability in hydrated condition and thereby limits its application for bone tissue regeneration. Thus in the present study, to overcome the limitations associated with chitosan based scaffolds, we fabricated polyelectrolyte complexation mediated composite scaffol...
Abstract Fabrication of gelatin/polyvinyl alcohol/chondroitin sulfate (GEL/PVA/CS) hybrid nanofibrous scaffolds using acetic acid and water as an environmentally friendly solvent system via electrospinning for skin tissue engineering was investigated. Modeling and optimization of the nanofibers were performed using response surface methodology (RSM). The influence of CS ratio on mechanical, physical and biological properties of the nanofibers was studied. PVA was used as a carrier and enhancer o...
Abstract Progress at elimination of malaria is limited by the challenges of reaching large rural population and ensuring patient adherence to adequate pharmacologic treatment. In the present study, a novel material (octadecylamine modified chondroitin sulfate) was synthesized, to fabricate a long acting release meshy gel system as an efficient weapon for protracted warfare to malaria. Ivermectin loaded meshy gels (IVM-MG) composed of different amount of phospholipids, triglyceride and modified c...
#1Ma Fenbo(Southern University of Science and Technology)H-Index: 2
#2Xia Xingyu(HKU: University of Hong Kong)H-Index: 1
Last. Tang Bin(Southern University of Science and Technology)H-Index: 2
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Abstract A membrane used for guided bone regeneration (GBR) serves as a bioactive compartment rather than a physical barrier. However, the pure membrane may not provide an optimal microenvironment for bone formation and remodeling. Here, a novel strontium chondroitin sulfate/silk fibroin (SrCS/SF) blend membrane containing microporous structure was fabricated. By increasing incorporation content of SrCS, SrCS/SF membranes exhibit better mechanical properties and higher water retention capacity. ...
Abstract The purpose of this study was to ascertain the effect of chondroitin sulphate-modified doxorubicin (Dox) nanoparticles on enhancing the tumour-targeting effect and tumour growth inhibition effect of doxorubicin both in vitro and in vivo. The chondroitin sulphate-doxorubicin conjugate and its poly(lactic-co-glycolic acid) (PLGA) nanoparticles (CS-Dox-PLGA) were successfully synthesised, and then characterized by Fourier-transform infrared spectroscopy (FTIR), proton magnetic resonance (1...
Last. Ping Yang(Southwest Jiaotong University)H-Index: 33
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Abstract Surface functionalization is generally accepted as one of the most useful methods for endowing better biocompatibility of the cardiovascular implants. Chondroitin sulfate (CS) is a commercial drug applied for preventing cardiovascular diseases in clinics, suggesting a potential application for functionalized coatings. Our previous work demonstrated that the CS conjugated onto the poly-dopamine (PDA)/hexanediamine (HD) co-deposited 316L stainless steel (316L SS) could endow the surface s...
Last. Junqiang Fang(SDU: Shandong University)H-Index: 9
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Abstract null null The non-sulfated chondroitin backbone (CH) is the synthetic precursor of chondroitin sulfate, a linear polysaccharide with dramatic biological functions. Owing to the intrinsic characteristics of the polysaccharide biosynthetic pathway, it is still a challenge to obtain structural-defined glycans via microbial fermentation or enzymatic synthesis, which hindering the illustration of CH polysaccharide functions. Herein, we report a robust one-pot multi-enzyme polysaccharide remo...
Last. Jianhua Xie(NCU: Nanchang University)H-Index: 35
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Abstract null null The shortage of freshwater resources is an urgent problem worldwide, especially for some areas that lack rainfall conditions. The development of reliable wastewater treatment and freshwater harvesting equipment has become an urgent demand. Hydrogel is a porous 3D network structure with good pollutant adsorption capacity, water holding capacity, water adsorption capacity, and reversible swelling ability, which has been widely used in water treatment. Chitosan (CH), as the abund...
Abstract null null Stable and biocompatible collagen-based hydrogels based on natural extracellular matrix (ECM) with a homogeneous microstructure are ideal scaffolds for tissue engineering; however, lack of structural stability and mechanical property have hindered their application. In this work, Chondroitin Sulfate (CS) was periodate-oxidized to prepare dialdehyde ECM-derived biopolymer with the weight average molecular weight of 3.7 × 104 g/moL to construct the stable collagen-based fibrilla...
Last. Derrick Dean(Alabama State University)H-Index: 3
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Abstract null null We report herein the fabrication of a pectin-based scaffold (6 wt% pectin, 3 wt% alginate) with high resolution (small-diameter rods), small pores, and interconnected porosity using a low temperature 3D printing process known as freeze-printing. The ability to successfully print natural polymers has been a long-standing challenge in the field of additive manufacturing of polymeric tissue scaffolds. This is due to the slow evaporation rate of the aqueous solvent, which leads to...
Natural products can be used as natural radiosensitizers and radioprotectors, showing promising effects in cancer treatments in combination with radiotherapy, while reducing ionizing radiation (IR) damage to normal cells/tissues. The different effects of natural products on irradiated normal and tumor cells/tissues have attracted more and more researchers' interest. However, their clinical applications of natural products in radiotherapy are few, which may be related to their low bioavailability...
Last. Yuanhui Zhao(Ocean University of China)H-Index: 15
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Abstract null null Sturgeon cartilage, which is rich in chondroitin sulfate (CS), is usually discarded during sturgeon utilization. In this paper, CS was isolated from large hybrid sturgeon skull and backbone and named SCS and BCS, respectively. Their structures were investigated via Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy and high performance liquid chromatography (HPLC). The average molecular weights of SCS and BCS were ~ 30–44 kDa. Disacc...
Chondroitin sulfate (CS) is a naturally derived bioactive macromolecule and has been used to improve the performance of silk fibroin (SF) biomaterials for soft tissue regeneration. However, it is still a challenge to use a chemical-free method to prepare water-insoluble SF/CS scaffolds. Here, a novel all-aqueous process was developed to prepare SF/CS scaffolds with controlled properties. Freezing-annealing treatment was used to induce silk I crystallization of SF to entrap CS macromolecules. It ...
Last. Edvani C. Muniz(UEM: Universidade Estadual de Maringá)H-Index: 59
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Abstract Important researches aim for the development of efficient and cheaper biomedical devices based on natural polysaccharides. In this facet, polyelectrolytes complexes (PECs) are interesting materials for biomedical purposes because they can be prepared without using conventional and volatile organic solvents and toxic crosslinkers, commonly used in the synthesis of chemical hydrogels. For the first time, we used ionic liquids (1-alkyl-3-methylimidazolium tetrafluoroborate ionic liquids, [...
