Soft tissue sarcoma: DWI and DCE-MRI parameters correlate with Ki-67 labeling index.

Published on Feb 1, 2020in European Radiology4.101
· DOI :10.1007/S00330-019-06445-9
Ji Hyun Lee10
Estimated H-index: 10
(SMC: Samsung Medical Center),
Ji-Hyun Lee2
Estimated H-index: 2
(SMC: Samsung Medical Center)
+ 2 AuthorsHyun Su Kim9
Estimated H-index: 9
(SMC: Samsung Medical Center)
Objectives To examine the correlation of diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging (MRI) parameters with Ki-67 labeling index (LI) in soft tissue sarcoma (STS).
📖 Papers frequently viewed together
15 Citations
#1Avneesh ChhabraH-Index: 36
#2Oganes AshikyanH-Index: 11
Last. Yin XiH-Index: 17
view all 8 authors...
Aim To evaluate proven soft tissue musculoskeletal malignancies blinded to their Federation Nationale des Centres de Lutte Contre le Cancer histologic grades to identify the predictive values of conventional MR findings and best fit region of interest (ROI) apparent diffusion coefficient (ADC) measurements.
19 CitationsSource
#1Amandine CrombéH-Index: 10
Last. Michèle KindH-Index: 21
view all 8 authors...
The presence of at least two of three MRI features (necrosis, heterogeneity, and peritumoral enhancement) was an independent predictor of metastasis-free survival and overall survival.
38 CitationsSource
#1Min A Yoon (UOU: University of Ulsan)H-Index: 3
#2Choong Guen Chee (UOU: University of Ulsan)H-Index: 4
Last. Myung Jin Shin (UOU: University of Ulsan)H-Index: 18
view all 9 authors...
Objectives This study was conducted to evaluate the added value of diffusion-weighted imaging (DWI) to conventional magnetic resonance imaging (MRI) for predicting fascial involvement of soft tissue sarcomas located in close proximity to fascial boundaries.
10 CitationsSource
#1Ji Hyun Lee (SMC: Samsung Medical Center)H-Index: 10
#1Ji-Hyun Lee (SMC: Samsung Medical Center)H-Index: 4
Last. Seonwoo Kim (SMC: Samsung Medical Center)H-Index: 52
view all 5 authors...
The objective of this study was to develop, validate, and compare nomograms for malignancy prediction in soft tissue tumors (STTs) using conventional and diffusion-weighted magnetic resonance imaging (MRI) measurements. Between May 2011 and December 2016, 239 MRI examinations from 236 patients with pathologically proven STTs were included retrospectively and assigned randomly to training (n = 100) and validation (n = 139) cohorts. MRI of each lesion was reviewed to assess conventional and diffus...
3 CitationsSource
1 CitationsSource
#1Mengtian Sun (Zhengzhou University)H-Index: 3
#2Jingliang Cheng (Zhengzhou University)H-Index: 10
Last. Zhenqian Li (Zhengzhou University)H-Index: 1
view all 7 authors...
Objectives We investigated the correlation between the apparent diffusion coefficient (ADC) and Ki-67 index using diffusion-weighted whole-body imaging with background body signal suppression (DWIBS), and their utility in evaluating malignant lymphoma cell proliferation.
16 CitationsSource
#1Soomin Ahn (Seoul National University Bundang Hospital)H-Index: 20
#1Soomin Ahn (Seoul National University Bundang Hospital)H-Index: 6
Last. Sun Hee Sung (Seoul National University Bundang Hospital)H-Index: 1
view all 5 authors...
Context.— The Ki-67 index is strongly prognostic and is used as a surrogate marker to distinguish luminal A from luminal B breast cancer types. Objective.— To investigate differences in Ki-67 index between core needle biopsy samples and matched surgical samples in breast cancer. Design.— We included patients with invasive breast cancer who did not receive neoadjuvant therapy. A total of 89 pairs of core needle biopsies and surgical specimens were collected, and the Ki-67 index was assessed in ho...
9 CitationsSource
#1Young Bin Song (Hanyang University)H-Index: 33
#2Yeup Yoon (SKKU: Sungkyunkwan University)H-Index: 20
Last. Mi-Suk Kim (Samsung)H-Index: 12
view all 7 authors...
Aim To compare the abilities of conventional magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) in differentiating between benign and malignant soft-tissue tumours (STT). Material and methods A total of 123 patients with STT who underwent 3 T MRI, including diffusion-weighted imaging (DWI), were retrospectively analysed using variate conventional MRI parameters, ADCmean and ADCmin. Results For the all-STT group, the correlation between the malignant STT conventional MRI pa...
14 CitationsSource
#1Koji Sagiyama (Kyushu University)H-Index: 9
#2Yuji Watanabe (Kyushu University)H-Index: 3
Last. Hiroshi Honda (Kyushu University)H-Index: 79
view all 7 authors...
Objectives To investigate the usefulness of voxel-based analysis of standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs) for evaluating soft-tissue tumour malignancy with a PET/MR system.
11 CitationsSource
#1Alexey SurovH-Index: 25
#2Hans Jonas Meyer (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 18
Last. Patrick StumppH-Index: 12
view all 7 authors...
Abstract BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) can characterize perfusion and vascularization of tissues. DCE MRI parameters can differentiate between malignant and benign lesions and predict tumor grading. The purpose of this study was to correlate DCE MRI findings and various histopathological parameters in head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: Sixteen patients with histologically proven HNSCC (11 cases primary tumors and in 5...
26 CitationsSource
Cited By13
#1Oganes Ashikyan (UTSW: University of Texas Southwestern Medical Center)H-Index: 11
#2Stanley B. Bradshaw (UTSW: University of Texas Southwestern Medical Center)
Last. Avneesh Chhabra (UTSW: University of Texas Southwestern Medical Center)H-Index: 36
view all 5 authors...
Abstract Objectives Synovial sarcomas commonly involve extremities. The purpose of this study was to systematically assess and describe the appearance of pathologically proven synovial sarcomas on conventional MR sequences, diffusion weighted imaging and dynamic contrast enhanced imaging. Methods In this cross-sectional retrospective study, fifteen pre-operative MRIs were analyzed separately by two musculoskeletal radiologists and a fellow. MRI features of synovial sarcomas were evaluated in a s...
#1Yongsheng Zhang (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
#2Zhiping Li (ZJNU: Zhejiang Chinese Medical University)
Last. Maosheng Xu (ZJNU: Zhejiang Chinese Medical University)H-Index: 8
view all 10 authors...
PURPOSE To investigate whether preoperative histogram parameters of dynamic contrast-enhanced MRI (DCE-MRI) can assess the expression of Ki-67 in prostate cancer (PCa). MATERIALS AND METHODS A consecutive series of 76 patients with pathology-proven PCa who underwent routine DCE-MRI scans were retrospectively recruited. Quantitative parameters including the volume transfer constant (Ktrans ), rate contrast (Kep ), extracellular-extravascular volume fraction (Ve ), and plasma volume (Vp ) by outli...
#3Benedikt M. Schaarschmidt (University of Duisburg-Essen)H-Index: 9
Background: To evaluate the potential of simultaneously acquired 18F-FDG PET- and MR-derived quantitative imaging data sets of primary soft-tissue sarcomas for the prediction of neoadjuvant treatment response, the metastatic status and tumor grade. Methods: A total of 52 patients with a high-risk soft-tissue sarcoma underwent a 18F-FDG PET/MR examination within one week before the start of neoadjuvant treatment. For each patient, the maximum tumor size, metabolic activity (SUVs), and diffusion-r...
#1Vito Chianca (UniPi: University of Pisa)
#2Domenico Albano (University of Palermo)H-Index: 24
Last. Luca Maria Sconfienza (University of Milan)H-Index: 37
view all 7 authors...
In the last two decades, relevant progress has been made in the diagnosis of musculoskeletal tumors due to the development of new imaging tools, such as diffusion-weighted imaging, diffusion kurtosis imaging, magnetic resonance spectroscopy, and diffusion tensor imaging. Another important role has been played by the development of artificial intelligence software based on complex algorithms, which employ computing power in the detection of specific tumor types. The aim of this article is to repo...
#1Ji Hyun Lee (SMC: Samsung Medical Center)H-Index: 10
#2Gyu Sang Yoo (SMC: Samsung Medical Center)H-Index: 7
Last. Hyun Su Kim (SMC: Samsung Medical Center)H-Index: 9
view all 5 authors...
The objectives of this study were to assess changes in apparent diffusion coefficient (ADC) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters after radiation therapy (RT) for bone metastases from hepatocellular carcinoma (HCC) and to evaluate their prognostic value. This prospective study was approved by the Institutional Review Board. Fourteen patients with HCC underwent RT (30 Gy in 10 fractions once daily) for bone metastases. The ADC and DCE-MRI parameters and t...
#1Soumya Ranjan Malla (AIIMS: All India Institute of Medical Sciences)
#2Ashu Seith Bhalla (AIIMS: All India Institute of Medical Sciences)H-Index: 15
Last. Aanchal Kakkar (AIIMS: All India Institute of Medical Sciences)H-Index: 7
view all 8 authors...
BACKGROUND AND PURPOSE Morphological assessment with conventional magnetic resonance imaging (MRI) sequences has limited specificity to distinguish between paragangliomas and schwannomas. Assessing the differences in microvascular properties through pharmacokinetic parameters of dynamic contrast-enhanced (DCE)-MRI can provide additional information to aid in this differentiation. MATERIALS AND METHODS A prospective study on MR characterization of neck masses was performed between January 2017 an...
BACKGROUND In the diagnosis of bone and soft-tissue sarcomas, the continuous advancement of various imaging modalities has improved the detection of small lesions, surgical planning, assessment of chemotherapeutic effects, and, importantly, guidance for surgery or biopsy. METHOD This review was composed based on a PubMed literature search for the terms "bone sarcoma," "bone cancer" and "soft tissue sarcoma," "imaging," "magnetic resonance imaging", "computed tomography", "ultrasound", "radiograp...
#1Gauthier DodinH-Index: 2
#2Julia SalleronH-Index: 35
view all 7 authors...
To evaluate the added value of DWI, qualitative proton MR spectroscopy (H-MRS) and dynamic contrast-enhanced perfusion (DCE-P) to conventional MRI in differentiating benign and malignant non-fatty soft tissue tumors (NFSTT). From November 2009 to August 2017, 288 patients with NFSTT that underwent conventional and advanced MRI were prospectively evaluated. The study was approved by the local ethics committee. All patients signed an informed consent. A musculoskeletal (R1) and a general (R2) radi...
1 CitationsSource
#1Xiangwen Li (Dalian Medical University)H-Index: 2
#2Lin Yang (Dalian Medical University)H-Index: 1
Last. Shaowu Wang (Dalian Medical University)H-Index: 6
view all 6 authors...
OBJECTIVE To investigate the correlation of intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) parameters with the expression of HIF-1α in soft tissue sarcoma (STS). METHODS This prospective study was approved by the institutional ethics committee. Written informed consent was obtained from all patients. Forty patients with STS who underwent 3.0 T MRI, including IVIM and DKI, were included in the study. Standard apparent diffusion coefficient (ADC), true ADC (Dslow), pseudo...
1 CitationsSource
#1Pingping Wang (Nanjing Medical University)H-Index: 1
#2Hai Li (Nanjing Medical University)
Last. Ao Li (Nanjing Medical University)H-Index: 1
view all 7 authors...
Objectives To explore the relationship between ultrasound (US) features and Ki-67 labeling index (LI) of soft tissue sarcoma (STS). Methods Forty-six patients with 47 STS lesions, between September 2014 and April 2020, were enrolled in the study. Point-biserial correlation analysis and Spearman's correlation analysis were utilized to examining the relationship between the US features and the Ki-67 LI of STS. The differences of US features between high and low Ki-67 proliferation groups were stat...