Original paper
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal
Abstract
Endomembrane damage elicits homeostatic responses including ESCRT-dependent membrane repair and autophagic removal of damaged organelles. Previous studies have suggested that these systems may act separately. Here, we show that galectin-3 (Gal3), a β-galactoside-binding cytosolic lectin, unifies and coordinates ESCRT and autophagy responses to lysosomal damage. Gal3 and its capacity to recognize damage-exposed glycans were required for efficient...
Paper Details
Title
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal
Published Date
Jan 1, 2020
Journal
Volume
52
Issue
1
Pages
69 - 87.e8
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Notes
History