Aurore Claude-Taupin
University of New Mexico
EndosomeTFEBFunction (biology)ESCRTGalectinSecretory proteinIntegral membrane proteinPhagosomeOrganelleMAP3K7ReceptorPyroptosisHEK 293 cellsChemistryCytoplasmAutophagyEndomembrane systemInflammasomeMechanistic target of rapamycinGuanosineCytokineTriphosphataseIQGAP1Context (language use)AMPKLysosomeIRGMVirulence factorMitochondrionSyntaxin 17Membrane integrityMolecular mechanismOn pathwayBroad spectrumTransferrin receptorMembraneSecretionBiochemistrySignal transductionULK1Gene knockoutIntracellularPI3K/AKT/mTOR pathwayBiologyImmune systemCell biologyProtein kinase ACytosolBAG3
9Publications
7H-index
316Citations
Publications 9
Newest
#7Ruheena Javed (UNM: University of New Mexico)H-Index: 7
The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad intracellular distribution and is present in numerous compartments, including the plasma membrane (PM). The reasons for the distribution of ATG9A to the PM and its role at the PM are not understood. Here, we show that ATG9A organizes, in concert with IQGAP1, components of the ESCRT system and uncover cooperation between ATG9A, IQGAP1 and ESCRTs in protection from PM damage. ESCRTs and ATG9A phenocopied each ot...
1 CitationsSource
#1Jingyue Jia (UNM: University of New Mexico)H-Index: 13
#2Aurore Claude-Taupin (UNM: University of New Mexico)H-Index: 7
Last. Vojo Deretic (UNM: University of New Mexico)H-Index: 111
view all 15 authors...
Membrane integrity is essential for cellular survival and function. The spectrum of mechanisms protecting cellular and intracellular membranes is not fully known. Our recent work has uncovered a ce...
4 CitationsSource
#1Jingyue Jia (UNM: University of New Mexico)H-Index: 13
#2Aurore Claude-Taupin (UNM: University of New Mexico)H-Index: 7
Last. Vojo Deretic (UNM: University of New Mexico)H-Index: 111
view all 15 authors...
Summary Endomembrane damage elicits homeostatic responses including ESCRT-dependent membrane repair and autophagic removal of damaged organelles. Previous studies have suggested that these systems may act separately. Here, we show that galectin-3 (Gal3), a β-galactoside-binding cytosolic lectin, unifies and coordinates ESCRT and autophagy responses to lysosomal damage. Gal3 and its capacity to recognize damage-exposed glycans were required for efficient recruitment of the ESCRT component ALIX du...
55 CitationsSource
#1Jingyue Jia (UNM: University of New Mexico)H-Index: 13
#2Yakubu Princely Abudu (University of Tromsø)H-Index: 10
Last. Vojo Deretic (UNM: University of New Mexico)H-Index: 111
view all 13 authors...
ABSTRACTThe Ser/Thr protein kinase MTOR (mechanistic target of rapamycin kinase) regulates cellular metabolism and controls macroautophagy/autophagy. Autophagy has both metabolic and quality control functions, including recycling nutrients at times of starvation and removing dysfunctional intracellular organelles. Lysosomal damage is one of the strongest inducers of autophagy, and yet mechanisms of its activation in response to lysosomal membrane damage are not fully understood. Our recent study...
36 CitationsSource
#1Jingyue Jia (UNM: University of New Mexico)H-Index: 13
#2Yakubu Princely Abudu (University of Tromsø)H-Index: 10
Last. Vojo Deretic (UNM: University of New Mexico)H-Index: 111
view all 13 authors...
Summary The Ser/Thr protein kinase mTOR controls metabolic pathways, including the catabolic process of autophagy. Autophagy plays additional, catabolism-independent roles in homeostasis of cytoplasmic endomembranes and whole organelles. How signals from endomembrane damage are transmitted to mTOR to orchestrate autophagic responses is not known. Here we show that mTOR is inhibited by lysosomal damage. Lysosomal damage, recognized by galectins, leads to association of galectin-8 (Gal8) with the ...
94 CitationsSource
#1Aurore Claude-Taupin (UNM: University of New Mexico)H-Index: 7
#2Bhawana Bissa (UNM: University of New Mexico)H-Index: 7
Last. Vojo Deretic (UNM: University of New Mexico)H-Index: 111
view all 5 authors...
Abstract The autophagy pathway known also as macroautophagy (herein referred to as autophagy) is characterized by the formation of double-membrane organelles that capture cytosolic material. Based on pathway termination alternatives, autophagy has been divided into degradative and secretory. During degradative autophagy, autophagosomes typically fuse with lysosomes upon which the sequestered material is degraded. During secretory autophagy, instead of degradation the sequestered cargo is subject...
31 CitationsSource
#1Suresh Kumar (UNM: University of New Mexico)H-Index: 20
#2Ashish Jain (University of Oslo)H-Index: 24
Last. Vojo Deretic (UNM: University of New Mexico)H-Index: 111
view all 12 authors...
Autophagy is a conserved eukaryotic process with metabolic, immune, and general homeostatic functions in mammalian cells. Mammalian autophagosomes fuse with lysosomes in a SNARE-driven process that includes syntaxin 17 (Stx17). How Stx17 translocates to autophagosomes is unknown. In this study, we show that the mechanism of Stx17 recruitment to autophagosomes in human cells entails the small guanosine triphosphatase IRGM. Stx17 directly interacts with IRGM, and efficient Stx17 recruitment to aut...
70 CitationsSource
#1Aurore Claude-Taupin (UNM: University of New Mexico)H-Index: 7
#2Jingyue Jia (UNM: University of New Mexico)H-Index: 13
Last. Vojo Deretic (UNM: University of New Mexico)H-Index: 111
view all 4 authors...
Autophagy is conventionally described as a degradative, catabolic pathway and a tributary to the lysosomal system where the cytoplasmic material sequestered by autophagosomes gets degraded. However, autophagosomes or autophagosome-related organelles do not always follow this route. It has recently come to light that autophagy can terminate in cytosolic protein secretion or release of sequestered material from the cells, rather than in their degradation. In this review, we address this relatively...
30 CitationsSource
#1Tomonori Kimura (UNM: University of New Mexico)H-Index: 33
#2Jingyue Jia (UNM: University of New Mexico)H-Index: 13
Last. Terje Johansen (University of Tromsø)H-Index: 78
view all 16 authors...
ABSTRACTMacroautophagy/autophagy plays a role in unconventional secretion of leaderless cytosolic proteins. Whether and how secretory autophagy diverges from conventional degradative autophagy is unclear. We have shown that the prototypical secretory autophagy cargo IL1B/IL-1β (interleukin 1 β) is recognized by TRIM16, and that this first to be identified secretory autophagy receptor interacts with the R-SNARE SEC22B to jointly deliver cargo to the MAP1LC3B-II-positive sequestration membranes. C...
42 CitationsSource