The potential of serpins for future treatment for haemophilia

Serpins (serine protease inhibitors) are the largest family of protease inhibitors and include several key players in the regulation of coagulation. Antithrombin, protein C inhibitor (PCI), α1-antitrypsin (α1AT), protein Z-dependent protease inhibitor (ZPI), and heparin cofactor II are examples of members of this superfamily of protease inhibitors.1 The molecular mechanisms behind the serpin functions are somewhat different from the majority of...