Current management of Cushing's disease

Cushing's disease ( CD ) is caused by a pituitary tumour that secretes adrenocorticotropin ( ACTH ) autonomously, leading to excess cortisol secretion from the adrenal glands. The condition is associated with increased morbidity and mortality that can be mitigated by treatments that result in sustained endocrine remission. Transsphenoidal pituitary surgery ( TSS ) remains the mainstay of treatment for CD but requires considerable neurosurgical...