Deformable Biomaterials Based on Ultralong Hydroxyapatite Nanowires.

Published on Sep 6, 2019in ACS Biomaterials Science & Engineering4.152
· DOI :10.1021/ACSBIOMATERIALS.9B01183
Ying-Jie Zhu81
Estimated H-index: 81
(CAS: Chinese Academy of Sciences),
Bing-Qiang Lu22
Estimated H-index: 22
(CAS: Chinese Academy of Sciences)
Hydroxyapatite (HAP) biomaterials with high biocompatibility, bioactivity, and osteoconductivity/osteoinductivity have many applications in the biomedical fields. The traditional HAP materials usually feature high brittleness. Although hybridizing HAP with polymers can obtain deformable materials, their deformability is mainly contributed by polymers. Recently, research progress has been made in the deformable HAP biomaterials with high flexibility, softness, or elasticity based on ultralong HAP nanowires (UHANWs). This article provides a brief review on the recent progress on this research topic. Specifically, the strategy is proposed for solving the high brittleness of HAP biomaterials using UHANWs; the synthetic strategies for UHANWs are presented; and a variety of deformable biomaterials based on UHANWs are discussed. This review article provides a new concept of deformable biomaterials consisting of UHANWs and will stimulate new research works on deformable HAP biomaterials and further contribute to ...
📖 Papers frequently viewed together
12 Citations
1 Citations
10 Citations
Cited By5
#1Ying-Jie Zhu (CAS: Chinese Academy of Sciences)H-Index: 81
#2Yoshinaka ShimizuH-Index: 17
Last. Ying‐Jie Zhu (CAS: Chinese Academy of Sciences)
view all 8 authors...
This study was conducted in order to investigate biological compatibility of a thin and flexible hydroxyapatite (HAP) paper which consists of ultralong hydroxyapatite nanowires. Circular-shaped cranial bone defects with a diameter of 8.8 mm were prepared to expose the dura maters in Wistar rats. The similar-sized, circular-shaped HAP paper was placed at the bottom of the bone defects. After 2, 4, and 8 weeks, the rats were sacrificed, and the experimental sections were examined by micro-CT scann...
#1Heng Li (CAS: Chinese Academy of Sciences)H-Index: 92
#2Ying-Jie Zhu (CAS: Chinese Academy of Sciences)H-Index: 81
#1Behrad Ghiasi (Shahid Beheshti University)H-Index: 2
#2Yahya Sefidbakht (Shahid Beheshti University)H-Index: 8
Last. Vuk Uskoković (UCI: University of California, Irvine)H-Index: 34
view all 9 authors...
The synthetic analogue to biogenic apatite, hydroxyapatite (HA) has a number of physicochemical properties that make it an attractive candidate for diagnosis, treatment of disease and augmentation ...
13 CitationsSource
#1Michele Anselmi (UNIBO: University of Bologna)H-Index: 3
#2Pasquale Stavole (UNIBO: University of Bologna)H-Index: 1
Last. Luca Gentilucci (UNIBO: University of Bologna)H-Index: 24
view all 6 authors...
Aim: The pharmaceutical industry is showing renewed interest in therapeutic peptides. Unfortunately, the chemical synthesis of peptides remains very expensive and problematic in terms of environmen...
8 CitationsSource