Amyloid burden and white matter hyperintensities mediate age-related cognitive differences
Abstract
This study examined the additive versus synergistic contribution of beta-amyloid (Aβ) and white matter hyperintensities (WMHs) across 7 cognitive domains in 104 cognitively normal older adults. It also measured the extent to which age-related differences in cognition are driven by measurable brain pathology. All participants underwent neuropsychological assessment along with magnetic resonance imaging and Pittsburg compound B-positron emission...
Paper Details
Title
Amyloid burden and white matter hyperintensities mediate age-related cognitive differences
Published Date
Feb 1, 2020
Journal
Volume
86
Pages
16 - 26
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