Hydrogel-Based Therapy for Brain Repair After Intracerebral Hemorrhage.

Published on Jun 1, 2020in Translational Stroke Research5.78
· DOI :10.1007/S12975-019-00721-Y
Teck Chuan Lim9
Estimated H-index: 9
(MIT: Massachusetts Institute of Technology),
Emiri T. Mandeville20
Estimated H-index: 20
(Harvard University)
+ 6 AuthorsMyron Spector67
Estimated H-index: 67
(Brigham and Women's Hospital)
We assessed an injectable gelatin hydrogel containing epidermal growth factor (Gtn-EGF) as a therapy for intracerebral hemorrhage (ICH). ICH was induced in rats via collagenase injection into the striatum. Two weeks later, Gtn-EGF was injected into the cavitary lesion. The hydrogel filled ICH cavities without deforming brain tissue. Immunostaining demonstrated that neural precursor cells could migrate into the matrix, and some of these differentiated into neurons along with the appearance of astrocytes, oligodendrocytes, and endothelial cells. Sensorimotor tests suggested that Gtn-EGF improved neurological recovery. This study provides proof-of-principle that injectable biomaterials may be a translationally relevant approach for treating ICH.
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