Original paper

Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation

Neuron16.20
Volume: 104, Issue: 2, Pages: 338 - 352.e7
Published: Oct 1, 2019
Abstract
Conventional antidepressants have limited efficacy and many side effects, highlighting the need for fast-acting and specific medications. Induction of the synaptic protein Homer1a mediates the effects of different antidepressant treatments, including the rapid action of ketamine and sleep deprivation (SD). We show here that mimicking Homer1a upregulation via intravenous injection of cell-membrane-permeable TAT-Homer1a elicits rapid...
Paper Details
Title
Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation
Published Date
Oct 1, 2019
Journal
Volume
104
Issue
2
Pages
338 - 352.e7
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