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#1Erica L. Gorenberg (UPenn: University of Pennsylvania)
#2James Shorter (UPenn: University of Pennsylvania)H-Index: 58
Protein aggregates can sequester RNA in neurodegenerative disease, but the exact RNAs sequestered by tau inclusions have remained uncharacterized. In this issue of Neuron, Lester et al. (2021) begin to identify these RNAs and reveal related perturbations in nuclear speckles.
#1Sten Grillner (KI: Karolinska Institutet)H-Index: 71
#2William Scott Thompson (KI: Karolinska Institutet)
In this issue of Neuron, McElvain et al. (2021) show that the major output of the basal ganglia, the substantia nigra pars reticulata, targets no fewer than 42 midbrain and brainstem structures and conveys an efference copy of the downstream commands back via thalamus to the cortex and striatum.
#1Asaf Gilboa (U of T: University of Toronto)H-Index: 31
#2Morris Moscovitch (U of T: University of Toronto)H-Index: 99
Summary Memory systems consolidation is often conceived as the linear, time-dependent, neurobiological shift of memory from hippocampal-cortical to cortico-cortical dependency. We argue that contrary to this unidirectional view of memory reorganization, information about events may be retained in multiple forms (e.g., event-specific sensory-near episodic memory, event-specific gist information, event-general schematic information, or abstract semantic memory). These representations can all form ...
#1Yangkyun OhH-Index: 6
#2Jason Sih Yu LaiH-Index: 3
Last. Greg S. B. Suh (KAIST)
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Summary Nutrient sensors allow animals to identify foods rich in specific nutrients. The Drosophila nutrient sensor, diuretic hormone 44 (DH44) neurons, helps the fly to detect nutritive sugar. This sensor becomes operational during starvation; however, the mechanisms by which DH44 neurons or other nutrient sensors are regulated remain unclear. Here, we identified two satiety signals that inhibit DH44 neurons: (1) Piezo-mediated stomach/crop stretch after food ingestion and (2) Neuromedin/Hugin ...
#1Matthias Kneussel (UHH: University of Hamburg)H-Index: 36
#2Manuel A. Friese (UHH: University of Hamburg)H-Index: 35
Neuronal function relies on tightly controlled cytoskeleton transport with adaptive cargo trafficking as prerequisite for synaptic transmission. During inflammation in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), axonal transport efficiency declines, followed by neurodegeneration. Furthermore, neuroinflammation causes an imbalance between excitatory and inhibitory transmission, triggering synaptic dysfunction and loss. Recent data suggest that neuronal transport a...
#1Vedrana Cvetkovska (McGill University)H-Index: 1
#2Rosemary C. Bagot (McGill University)H-Index: 9
Wang et al. (2021) characterize the molecular, cellular, and circuit-level role of Oligophrenin-1 in prefrontal parvalbumin interneurons, demonstrating that loss of Ophn1 function in these neurons is a mechanism for increased susceptibility to stress in intellectual disability caused by OPHN1 mutations.
#1Chie Satou (FMI: Friedrich Miescher Institute for Biomedical Research)H-Index: 11
#2Rainer W. Friedrich (FMI: Friedrich Miescher Institute for Biomedical Research)H-Index: 38
In this issue of Neuron, Gurnani and Silver (2021) report that activity across Golgi cells, a major type of inhibitory interneuron in the cerebellar cortex, is multidimensional and modulated by behavior. These results suggest multiple functions for inhibition in cerebellar computations.
#1Michael Moutoussis (UCL: University College London)H-Index: 24
#2Benjamín Garzón (KI: Karolinska Institutet)H-Index: 4
Last. Raymond J. Dolan (UCL: University College London)H-Index: 180
view all 47 authors...
Summary Decision-making is a cognitive process of central importance for the quality of our lives. Here, we ask whether a common factor underpins our diverse decision-making abilities. We obtained 32 decision-making measures from 830 young people and identified a common factor that we call “decision acuity,” which was distinct from IQ and reflected a generic decision-making ability. Decision acuity was decreased in those with aberrant thinking and low general social functioning. Crucially, decis...
#1Gesa Hartwigsen (MPG: Max Planck Society)H-Index: 23
#2Yoshua Bengio (UdeM: Université de Montréal)H-Index: 160
Last. Danilo Bzdok (McGill University)H-Index: 34
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Summary Uniquely human cognitive faculties arise from flexible interplay between specific local neural modules, with hemispheric asymmetries in functional specialization. Here, we discuss how these computational design principles provide a scaffold that enables some of the most advanced cognitive operations, such as semantic understanding of world structure, logical reasoning, and communication via language. We draw parallels to dual-processing theories of cognition by placing a focus on Kahnema...
#1Jacinta Conroy (UQ: University of Queensland)H-Index: 2
#2Dhanisha J. Jhaveri (UQ: University of Queensland)H-Index: 17
Last. Elizabeth J. Coulson (UQ: University of Queensland)H-Index: 33
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The mechanism by which antidepressants elicit clinical improvements has proven elusive. In a recent publication in Cell, Casarotto et al. (2021) reveal a surprising direct interaction between antidepressants and TrkB. This link provides an important mechanistic insight into synaptic remodeling that may assist in the design of improved antidepressant therapeutics.
Top fields of study
Cell biology