Original paper
Targeting HSP90 attenuates angiotensin II-induced adventitial remodelling via suppression of mitochondrial fission
Abstract
Aims Adventitial remodelling presenting with the phenotypic switch of adventitial fibroblasts (AFs) to myofibroblasts is reportedly involved in the evolution of several vascular diseases, including hypertension. In our previous study, we reported that heat shock protein 90 (HSP90) inhibition by 17-dime-thylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) markedly attenuates angiotensin II (AngII)-induced abdominal aortic aneurysm formation by...
Paper Details
Title
Targeting HSP90 attenuates angiotensin II-induced adventitial remodelling via suppression of mitochondrial fission
Published Date
Jul 25, 2019
Journal
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Notes
History