Gao-Jian Huang
Shanghai Jiao Tong University
Biomedical engineeringMitochondrial fissionChemistryMaterials scienceProgenitor cellMyofibroblastAdventitiaVascular endothelial growth factorBiocompatibilityDNM1LUmbilical veinNeovascularizationEnosMatrigelVascular smooth muscleAerogelEndothelial progenitor cellAngiogenesisPhenotypic switchingTherapeutic angiogenesisMitochondrionAngiotensin IIBone regenerationTube formationCancer researchHindlimbPorosityMedicineNanowireProtein kinase BAdhesionPI3K/AKT/mTOR pathwayScaffoldCell biologyPharmacology
Publications 4
#1Gao-Jian Huang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Han-Ping Yu (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Jun-Li Duan (SJTU: Shanghai Jiao Tong University)H-Index: 9
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Hydroxyapatite (HAP) is promising for the clinical treatment of bone defects because of its excellent biocompatibility and osteo-conductivity. However, highly porous HAP scaffolds usually exhibit high brittleness and poor mechanical properties, thus organic constituents are usually added to form composite materials. In this work, a highly porous and elastic aerogel made from ultralong HAP nanowires with ultrahigh porosity (∼98.5%), excellent elasticity and suitable porous structure is prepared a...
#1X. Wang (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Gao-Jian Huang (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Zhen Li (SJTU: Shanghai Jiao Tong University)H-Index: 12
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Background and aim: Modulating biological functions of endothelial progenitor cells (EPCs) is essential for therapeutic angiogenesis in ischemic vascular diseases. This study aimed to explore the role and molecular mechanisms of β-arrestin 2 (Arrb2) in EPCs biology and angiogenic therapy. Methods: The influence of Arrb2 on postischemic neovascularization was evaluated in Arrb2-deficient mice. The proliferation, apoptosis, and various functions of EPCs were analyzed in vitro by manipulating the e...
1 CitationsSource
#1Gao-Jian Huang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Zhilei Cong (Fudan University)H-Index: 1
Last. Jia Qi (SJTU: Shanghai Jiao Tong University)H-Index: 17
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AIMS: Adventitial remodeling presenting with the phenotypic switch of adventitial fibroblasts (AFs) to myofibroblasts (MFs) is reportedly involved in the evolution of several vascular diseases, including hypertension. In our previous study, we reported that heat shock protein 90 (HSP90) inhibition by 17-dime-thylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) markedly attenuates angiotensin II (AngII)-induced abdominal aortic aneurysm formation by simultaneously inhibiting several key signali...
11 CitationsSource
#1X. Wang (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Jia Qi (SJTU: Shanghai Jiao Tong University)H-Index: 17
Last. Jun-Li Duan (SJTU: Shanghai Jiao Tong University)H-Index: 9
view all 13 authors...
Statins and therapeutic ultrasound (TUS) have been shown to ameliorate angiogenesis on ischemic hindlimb animals and promote human umbilical vein endothelial cells (HUVECs) tube formation and proliferation. Here, we evaluate the therapeutic effect of TUS in combination with atorvastatin (Ator) therapy on angiogenesis in hindlimb ischemia and HUVECs. After subjecting excision of the left femoral artery, all mice were randomly distributed to one of four groups: Control; Ator treated mice (Ator); T...
7 Citations