Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Abstract
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2 allele conferring a decreased risk relative to the common APOE*ε3 allele. Strong evidence from clinical and basic research suggests that a major pathway by which APOE4 increases the risk of AD is by driving earlier and more abundant amyloid pathology in the...
Paper Details
Title
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Published Date
Jul 31, 2019
Journal
Volume
15
Issue
9
Pages
501 - 518
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