Prevalence, incidence, and mortality of nontuberculous mycobacterial infection in Korea: a nationwide population-based study

Published on Aug 1, 2019in BMC Pulmonary Medicine3.317
· DOI :10.1186/S12890-019-0901-Z
Chang Hoon Han9
Estimated H-index: 9
Sources
Abstract
Epidemiologic characteristics of nontuberculous mycobacterial (NTM) disease remain largely unknown. The objective of this study was to evaluate incidence, prevalence, and mortality of NTM infection in a large nationwide population-based cohort in Korea. Data of the National Health Insurance Service database, an extensive health-related database including most Korean residents, were used. Adults with a primary diagnosis of NTM as determined by International Classification of Disease-Tenth Revision coding (A31) were identified between 2003 and 2016. Incidence, prevalence, and mortality of NTM infection were analyzed. A total of 46,194 individuals had a primary diagnosis of NTM infection. Their mean age was 55.8 years. Of these subjects, 61.1% were females. Annual age-adjusted incidence and prevalence of NTM infection tended to increase rapidly from 2003 to 2016. Age-adjusted incidence and prevalence was 17.9 and 33.3 per 100,000 population in 2016. The incidence and prevalence were higher in females and the elderly. The 5-year mortality rate in the population with NTM infection was 17.8%. The standardized mortality ratio of patients with NTM infection to the general population was 2.16 (95% confidence interval: 2.10 to 2.22). This large population-based study showed that the incidence and prevalence of NTM infection in Korea increased rapidly from 2003 to 2016. They were higher in women and the elderly. The mortality rate in the population with NTM infection was higher than that in the general population.
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#1Doosoo Jeon (PNU: Pusan National University)H-Index: 15
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Previous UK studies investigating nontuberculous mycobacteria have been limited to reporting isolation from culture, not burden of disease. We assessed the burden of nontuberculous mycobacterial disease (NTMD) in UK primary care from 2006 to 2016. Using electronic healthcare records, we identified patients with NTMD using a strict definition including patients with guideline-directed treatment/monitoring. We described treatment regimens and incidence/prevalence in the general population and in p...
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#1Ryoung Eun Ko (SMC: Samsung Medical Center)H-Index: 4
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#1Charles S. Haworth (Papworth Hospital)H-Index: 34
#2John Banks (Abertawe Bro Morgannwg University Health Board)H-Index: 5
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The full guideline for the management of non-tuberculous mycobacterial pulmonary disease is published in Thorax . The following is a summary of the recommendations and good practice points. The sections referred to in the summary refer to the full guideline.
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#1Namhee Kim (PNU: Pusan National University)H-Index: 7
#2Jongyoun Yi (PNU: Pusan National University)H-Index: 14
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: Non-tuberculous mycobacteria (NTM) are being recognized increasingly as the causative agents of opportunistic infections in humans. This study investigated the epidemiologic trends of NTM recovery from various clinical specimens in 2 Korean tertiary-care hospitals. We reviewed the laboratory records of patient samples cultured for mycobacteria between 2009 and 2015 at 2 tertiary-care hospitals in Korea. The medical records for patients with positive NTM samples were also reviewed. During the s...
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#5Nakwon Kwak (Seoul National University Hospital)H-Index: 10
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