BMC Pulmonary Medicine
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#1Donato Lacedonia (University of Foggia)H-Index: 19
#2Giulia Scioscia (University of Foggia)H-Index: 6
Last. Maria P. Foschino-Barbaro (University of Foggia)H-Index: 19
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BACKGROUND Idiopathic Pulmonary Fibrosis (IPF) is a degenerative interstitial lung disease with both a poor prognosis and quality of life once the diagnosis is made. In the last decade many features of the disease have been investigated to better understand the pathological steps that lead to the onset of the disease and, moreover, different types of biomarkers have been tested to find valid diagnostic, prognostic and therapy response predictive ones. In the complexity of IPF, microRNA (miRNAs) ...
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#1Mengyue Guan (Capital Medical University)
#2Sun Ying (Capital Medical University)H-Index: 1
Last. Yuguang Wang (Capital Medical University)H-Index: 2
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BACKGROUND Previous studies suggest that transient receptor potential (TRP) channels and neurogenic inflammation may be involved in idiopathic pulmonary fibrosis (IPF)-related high cough sensitivity, although the details of mechanism are largely unknown. Here, we aimed to further explore the potential mechanism involved in IPF-related high cough sensitivity to capsaicin challenge in a guinea pig model of pulmonary fibrosis induced by bleomycin. METHODS Western blotting and real-time quantitative...
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#1Robert L. Camp (Yale University)H-Index: 67
#2Maxwell L. Smith (Mayo Clinic)H-Index: 22
Last. Robert J. Homer (Yale University)H-Index: 82
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BACKGROUND Current interstitial lung disease (ILD) diagnostic guidelines assess criteria across clinical, radiologic and pathologic domains. Significant interobserver variation in histopathologic evaluation has previously been shown but the specific source of these discrepancies is poorly documented. We sought to document specific areas of difficulty and develop improved criteria that would reduce overall interobserver variation. METHODS Using an internet-based approach, we reviewed selected ima...
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#1Sheng-Yuan Ruan (NTU: National Taiwan University)H-Index: 21
#2Chun-Ta Huang (NTU: National Taiwan University)H-Index: 22
Last. Huey-Dong Wu (NTU: National Taiwan University)H-Index: 19
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BACKGROUND Heterogeneity in acute respiratory distress syndrome (ARDS) has led to many statistically negative clinical trials. Etiology is considered an important source of pathogenesis heterogeneity in ARDS but previous studies have usually adopted a dichotomous classification, such as pulmonary versus extrapulmonary ARDS, to evaluate it. Etiology-associated heterogeneity in ARDS remains poorly described. METHODS In this retrospective cohort study, we described etiology-associated heterogeneity...
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#1Yusuke Gotoh (Fujita Health University)H-Index: 1
#2Teppei YamaguchiH-Index: 6
Last. Kazuyoshi Imaizumi (Fujita Health University)H-Index: 25
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BACKGROUND Pneumothorax is one complication of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS-TBB). We sought to clarify the risk factors for pneumothorax after EBUS-GS-TBB under fluoroscopic guidance. METHODS We retrospectively reviewed data from 916 patients who underwent EBUS-GS-TBB at Fujita Health University Hospital. We evaluated the following risk factors for pneumothorax after EBUS-GS-TBB: patient characteristics (sex, age, and pulmonary como...
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#1Lu Qin (ZJU: Zhejiang University)H-Index: 1
#2Fei-Zhou Zhang (ZJU: Zhejiang University)
Last. Lan-Fang Tang (ZJU: Zhejiang University)H-Index: 5
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BACKGROUND Idiopathic pulmonary hemosiderosis (IPH) encompasses a rare and agnogenic group of diffuse alveolar capillary hemorrhagic diseases. Corticosteroid treatment is the globally preferred therapeutic strategy for IPH; however, it can cause immunodeficiency. Nocardia infection often occurs in immunocompromised patients and primarily involves the pleura and lungs. Herein, we describe a case of pediatric pulmonary Nocardia infection after the corticosteroid treatment of IPH. CASE PRESENTATION...
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#1Ji Soo Choi (Yonsei University)H-Index: 9
#2Se Hyun Kwak (Yonsei University)H-Index: 1
Last. Eun Hye Lee (Yonsei University)H-Index: 8
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BACKGROUND Although depression is a common comorbidity of chronic obstructive pulmonary disease (COPD), the role of sex remains unexplored. We evaluated sex differences of risk factors of depressive symptoms in adults with COPD. METHODS This was a population-based cross-sectional study using data from the 2014 and 2016 Korea National Health and Nutrition Examination Survey. Spirometry was used to identify patients with COPD, defined as a FEV1/FVC ratio < 0.7. Presence of depressive symptoms was ...
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#2Mequannent Sharew Melaku (University of Gondar)
Last. Metadel AdaneH-Index: 5
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BACKGROUND Worldwide, pneumonia is the third leading cause of death in under 5 years children. Ethiopia is ranked 4th out of 15 countries having the highest burdens of the death rate among under-five children due to pneumonia. Regardless of this fact, efforts to identify determinants of pneumonia have been limited yet in Amhara region. This study was aimed to identify predictors of community-acquired childhood pneumonia among 2-59 months old children in the Amhara region, Ethiopia. METHODS Facil...
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#1Meihua Qiu (Beijing Chao-Yang Hospital)
#2Yuqing Chen (Capital Medical University)H-Index: 1
Last. Qiao Ye (Beijing Chao-Yang Hospital)
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BACKGROUND Asbestosis and silicosis are characterized by diffuse or nodular interstitial lung fibrosis resulting from exposure to asbestos or silica dust, respectively. This study was designed to detect programmed cell death protein (PD-1)/programmed death ligands (PD-Ls) expression in patients with asbestosis and silicosis and to explore the possible clinical significance of PD-1/PD-Ls expression in patients with the two diseases. METHODS Thirty patients with asbestosis, 23 patients with silico...
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#1Malou Janssen (EUR: Erasmus University Rotterdam)H-Index: 8
#2J Han J Meeder (EUR: Erasmus University Rotterdam)
Last. Corstiaan A. den Uil (EUR: Erasmus University Rotterdam)H-Index: 18
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BACKGROUND Acute respiratory distress syndrome (ARDS) often requires controlled ventilation, yielding high mechanical power and possibly further injury. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) can be used as a bridge to recovery, however, if this fails the end result is destroyed lung parenchyma. This condition is fatal and the only remaining alternative is lung transplantation. In the case study presented in this paper, lung transplantation was not an option given the critical...
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