The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
Abstract
Copy-number variants of the CYFIP1 gene in humans have been linked to autism spectrum disorders (ASD) and schizophrenia (SCZ), two neuropsychiatric disorders characterized by defects in brain connectivity. Here, we show that CYFIP1 plays an important role in brain functional connectivity and callosal functions. We find that Cyfip1-heterozygous mice have reduced functional connectivity and defects in white matter architecture, similar to...
Paper Details
Title
The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
Published Date
Aug 1, 2019
Journal
Volume
10
Issue
1
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