PMAA nanogel controllably releases anti-IL-1β IgY for treating allergic rhinitis

Intranasal glucocorticoid spray is the preferred method to treat allergic rhinitis. However, due to the instantaneous high drug concentration, there are still some side effects, such as nasal dryness, nasal bleeding and even systemic effect of glucocorticoid. Herein, a novel biocompatible poly(methacrylic acid) (PMAA) nanogel was synthesized and used to load anti-IL-1β IgY (IgY) for treating allergic rhinitis induced by ovalbumin. The results...