Proton pump inhibitor use and progression to major adverse renal events: a competing risk analysis

Background Proton pump inhibitors (PPIs) are associated with acute tubulointerstitial nephritis and there are reports associating their use with the development of chronic kidney disease (CKD). Aim To determine if PPI use is associated with major adverse renal events (MARE) in patients with CKD. Design Observational cohort study comprising patients with CKD attending secondary care renal clinics from 1 January 2006 until 31 December 2016....