Original paper
The Central Role of Protein Kinase C Epsilon in Cyanide Cardiotoxicity and Its Treatment
Abstract
In adult mouse myocytes, brief exposure to sodium cyanide (CN) in the presence of glucose does not decrease ATP levels, yet produces profound reduction in contractility, intracellular Ca2+ concentration ([Ca2+]i) transient and L-type Ca2+ current (ICa) amplitudes. We analyzed proteomes from myocytes exposed to CN, focusing on ionic currents associated with excitation-contraction coupling. CN induced phosphorylation of α1c subunit of L-type Ca2+...
Paper Details
Title
The Central Role of Protein Kinase C Epsilon in Cyanide Cardiotoxicity and Its Treatment
Published Date
Jun 7, 2019
Journal
Volume
171
Issue
1
Pages
247 - 257
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Notes
History