Salim Merali
Temple University
Ornithine decarboxylaseInternal medicineEndocrinologyUnfolded protein responseMolecular biologyEndoplasmic reticulumAdipose tissueChemistryImmunologySpermineRespiratory diseaseCOPDSpermidineLungPolyaminePneumocystis cariniiCancer researchBiochemistryMedicineBiologyMicrobiologyCell biologyCatabolismPharmacology
Publications 106
#9Cijo George Vazhappilly (UOS: University of Sharjah)H-Index: 3
#9Cijo George Vazhappilly (UOS: University of Sharjah)H-Index: 6
(1) Background: Today, the discovery of novel anticancer agents with multitarget effects and high safety margins represents a high challenge. Drug discovery efforts indicated that benzopyrane scaffolds possess a wide range of pharmacological activities. This spurs on building a skeletally diverse library of benzopyranes to identify an anticancer lead drug candidate. Here, we aim to characterize the anticancer effect of a novel benzopyrane derivative, aiming to develop a promising clinical antica...
#2Alla ArzumanyanH-Index: 9
Last. Mark A. FeitelsonH-Index: 39
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Abstract Chronic infection with hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma (HCC). The HBV encoded oncoprotein, HBx, alters the expression of host genes and the activity of multiple signal transduction pathways that contribute to the pathogenesis of HCC by multiple mechanisms independent of HBV replication. However, it is not clear which pathways are the most relevant therapeutic targets in hepatocarcinogenesis. Short chain fatty acids (SCFAs) h...
#1Jessica Molina-Franky (Del Rosario University)H-Index: 3
#2David F. PlazaH-Index: 9
Last. Manuel A. Patarroyo (Del Rosario University)H-Index: 28
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Abstract Successful Plasmodium falciparum invasion of red blood cells includes the orderly execution of highly specific receptor-ligand molecular interactions between the parasite's proteins and the red blood cell membrane proteins. There is a growing need for elucidating receptor-ligand pairings, which will help in understanding the parasite's biology and provide the fundamental basis for developing prophylactic or therapeutic alternatives leading to mitigating or eliminating this type of malar...
#1Shu-jen Chen (PSU: Pennsylvania State University)H-Index: 7
#2Lei Bao (PSU: Pennsylvania State University)H-Index: 49
Last. Barbara A. Miller (PSU: Pennsylvania State University)H-Index: 44
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Transient receptor potential melastatin 2 (TRPM2) ion channel has an essential function in maintaining cell survival following oxidant injury. Here, we show that TRPM2 is highly expressed in acute myeloid leukemia (AML). The role of TRPM2 in AML was studied following depletion with CRISPR/Cas9 technology in U937 cells. In in vitro experiments and in xenografts, depletion of TRPM2 in AML inhibited leukemia proliferation, and doxorubicin sensitivity was increased. Mitochondrial function including ...
4 CitationsSource
#1Antonio Di Meco (TU: Temple University)H-Index: 8
#2Jian-Guo Li (TU: Temple University)H-Index: 11
Last. Domenico Praticò (TU: Temple University)H-Index: 88
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A high circulating level of homocysteine (Hcy), also known as hyperhomocysteinemia, is a risk factor for Alzheimer’s disease (AD). Previous studies show that elevated Hcy promotes brain amyloidosis and behavioral deficits in mouse models of AD. However, whether it directly modulates the development of tau neuropathology independently of amyloid beta in vivo is unknown. Herein, we investigate the effect of diet-induced elevated levels of brain Hcy on the phenotype of a relevant mouse model of hum...
6 CitationsSource
#1Joseph Y. Cheung (TU: Temple University)H-Index: 69
#2Salim Merali (TU: Temple University)H-Index: 31
Last. Philippe Haouzi (PSU: Pennsylvania State University)H-Index: 23
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: In adult mouse myocytes, brief exposure to sodium cyanide (CN) in the presence of glucose does not decrease ATP levels, yet produces profound reduction in contractility, intracellular Ca2+ concentration ([Ca2+]i) transient and L-type Ca2+ current (ICa) amplitudes. We analyzed proteomes from myocytes exposed to CN, focusing on ionic currents associated with excitation-contraction coupling. CN induced phosphorylation of α1c subunit of L-type Ca2+ channel and α2 subunit of Na+-K+-ATPase. Methylen...
3 CitationsSource
#1Laura Goetzl (University of Texas at Austin)H-Index: 2
#1Laura Goetzl (University of Texas at Austin)H-Index: 25
Last. Mathieu E. Wimmer (TU: Temple University)H-Index: 18
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: Maternal opioid use disorder is common, resulting in significant neonatal morbidity and cost. Currently, it is not possible to predict which opioid-exposed newborns will require pharmacotherapy for neonatal abstinence syndrome. Further, little is known regarding the effects of maternal opioid use disorder on the developing human brain. We hypothesized that novel methodologies utilizing fetal central nervous system-derived extracellular vesicles isolated from maternal blood can address these ga...
3 CitationsSource
#1Akruti Patel (TU: Temple University)H-Index: 4
#2John C. Kostyak (TU: Temple University)H-Index: 4
Last. Satya P. Kunapuli (TU: Temple University)H-Index: 65
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Phosphatidylinositol 3-kinase is an important signaling molecule that, once activated, leads to the generation of phosphatidylinositol (3,4,5)-trisphosphate (PIP 3 ). We performed a proteomic screen to identify PIP 3 -interacting proteins in human platelets . Among these proteins, we found engulfment and cell motility 1 (ELMO1), a scaffold protein with no catalytic activity. ELMO1 is expressed in platelets and interacts with active RhoG. However, the function of ELMO1 in platelets is not known. ...
5 CitationsSource
#1Hanghang Zhang (TU: Temple University)H-Index: 4
#2Somnath Pandey (TU: Temple University)H-Index: 1
Last. Jean Pierre J. Issa (TU: Temple University)H-Index: 132
view all 33 authors...
Summary Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through RNAPII pause release. We now report that CDK9 is also essential for maintaining gene silencing at heterochromatic loci. Through a live cell drug screen with genetic confirmation, we discovered that CDK9 inhibition reactivates epigenetically silenced genes in cancer, leading to restored tumor suppressor gene expression, cell differentiation, and activation of endogenous retrovirus genes. CDK9 inhibition dephospho...
65 CitationsSource
#1Santhanam Shanmughapriya (TU: Temple University)H-Index: 27
#2Dhanendra Tomar (TU: Temple University)H-Index: 23
Last. Muniswamy Madesh (TU: Temple University)H-Index: 20
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Although many factors contribute to cellular differentiation, the role of mitochondria Ca2+ dynamics during development remains unexplored. Because mammalian embryonic epiblasts reside in a hypoxic environment, we intended to understand whether mCa2+ and its transport machineries are regulated during hypoxia. Tissues from multiple organs of developing mouse embryo evidenced a suppression of MICU1 expression with nominal changes on other MCU complex components. As surrogate models, we here utiliz...
9 CitationsSource