Toxicological Sciences
Papers 8,895
1 page of 890 pages (8,895 results)
#1J Morris (Rowan University)
#2E J Bealer (Rowan University)
Last. M M Staehle (Rowan University)
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The growing number of commercially-used chemicals that are under-evaluated for developmental neurotoxicity (DNT) combined with the difficulty in describing the etiology of exposure-related neurodevelopmental toxicity has created a reticent threat to human health. Current means of screening chemicals for DNT are limited to expensive, time-consuming, and labor-intensive traditional laboratory animal models. In this study, we hypothesize that exposed head regenerating planarian flatworms can effect...
#1Michael L. DoursonH-Index: 31
#2Lorna EwartH-Index: 17
Last. A. Wallace Hayes (USF: University of South Florida)H-Index: 10
view all 6 authors...
New approach methodologies (NAMs), including in vitro toxicology methods such as human cells from simple cell cultures to 3 D and organ-on-a-chip models of human lung, intestine, liver, and other organs, are challenging the traditional "norm" of current regulatory risk assessments. Uncertainty Factors continue to be used by regulatory agencies to account for perceived deficits in toxicology data. With the expanded use of human cell NAMs, the question "Are uncertainty factors needed when human ce...
#1Alexandra Denys (LSUHSC: Louisiana State University Health Sciences Center New Orleans)
#2Kim Brint Pedersen (LSUHSC: Louisiana State University Health Sciences Center New Orleans)H-Index: 13
Last. Martin J. J. Ronis (LSUHSC: Louisiana State University Health Sciences Center New Orleans)H-Index: 61
view all 10 authors...
Excessive ethanol consumption is a risk factor for osteopenia. Since a previous study showed that transgenic female mice with overexpression of catalase are partially protected from ethanol-mediated trabecular bone loss, we investigated the role of endogenous catalase in skeletal ethanol toxicity comparing catalase knockout to wild-type mice. We hypothesized that catalase depletion would exacerbate ethanol effects. The mice were tested in a newly designed binge ethanol model, in which 12-week-ol...
#1Ilona Bebenek (FDA : United States Food and Drug Administration)
Last. Claudia Wrzesinski (FDA : United States Food and Drug Administration)H-Index: 1
view all 8 authors...
COVID-19 (Coronavirus Disease 2019), the disease caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) is an ongoing global public health emergency. As understanding of the health effects of COVID-19 have improved, companies and agencies worldwide have worked together to identify therapeutic approaches, fast-track clinical trials and pathways for emergency use, and approve therapies for patients. This work has resulted in therapies that not only improve survival, reduce time of ...
#1Jie Ning (HMU: Hebei Medical University)H-Index: 4
#2Hairong Du (CDC: Centers for Disease Control and Prevention)
Last. Rong Zhang (HMU: Hebei Medical University)H-Index: 12
view all 10 authors...
The association between ambient airborne fine particulate matter (PM2.5) exposure and respiratory diseases has been investigated in epidemiological studies. To explore the potential mechanism of PM2.5-induced pulmonary fibrosis, sixty mice were divided into 3 groups to expose to different levels of PM2.5 for 8 and 16 weeks: filtered air (FA), unfiltered air (UA) and concentrated PM2.5 air (CA), respectively. BEAS-2B cells were treated with 0, 25, 50 and 100 μg/ml PM2.5 for 24 h. The biomarkers o...
#1Mayukh Banerjee (University of Louisville)H-Index: 2
#2Laila Al-Eryani (University of Louisville)H-Index: 7
Last. J. Christopher States (University of Louisville)H-Index: 33
view all 7 authors...
Cutaneous squamous cell carcinoma (cSCC) is a major deleterious health effect of chronic arsenic (iAs) exposure. The molecular mechanism of arsenic-induced cSCC remains poorly understood. We recently demonstrated that chronic iAs exposure leads to temporally regulated genome-wide changes in profiles of differentially expressed mRNAs and miRNAs at each stage of carcinogenesis (7, 19 and 28 weeks) employing a well-established passage-matched HaCaT cell line model of arsenic-induced cSCC. Here, we ...
#1Laura G. Sherlock (UCD: University of Colorado Denver)H-Index: 2
#2Durganili Balasubramaniyan (UCD: University of Colorado Denver)
Last. Clyde J. Wright (UCD: University of Colorado Denver)H-Index: 12
view all 10 authors...
Acetaminophen (APAP) overdose results in high morbidity and mortality, with limited treatment options. Increased understanding of the cellular signaling pathways activated in response to toxic APAP exposure is needed to provide insight into novel therapeutic strategies. Toxic APAP exposure induces hepatic nuclear factor kappa B (NFκB) activation. NFκB signaling has been identified to mediate the pro-inflammatory response, but also induces a pro-survival and regenerative response. It is currently...
#1Emma C. Bowers (UNC: University of North Carolina at Chapel Hill)H-Index: 4
#2Elizabeth M. Martin (NIH: National Institutes of Health)H-Index: 16
Last. Shaun D. McCullough (EPA: Environmental Protection Agency)H-Index: 11
view all 9 authors...
Inhaled chemical/material exposures are a ubiquitous part of daily life around the world. There is a need to evaluate potential adverse effects of both single and repeat exposures for thousands of chemicals and an exponentially larger number of exposure scenarios (e.g., repeated exposures). Meeting this challenge will require the development and use of in vitro new approach methodologies (NAMs); however, two major challenges face the deployment of NAMs in risk assessment are (1) characterizing w...
#1Angela Cruz-Hernandez (UM: University of Montana)
#2Ryan P. Mendoza (UM: University of Montana)H-Index: 4
Last. Jared M. Brown (UM: University of Montana)H-Index: 38
view all 8 authors...
Sulfur mustard (SM) has been widely used as a chemical warfare agent including most recently in Syria. Mice exposed to SM exhibit an increase in pro-inflammatory cytokines followed by immune cell infiltration in the lung, however, the mechanisms leading to these inflammatory responses has not been completely elucidated. Mast cells are one of the first responding innate immune cells found at the mucosal surfaces of the lung and have been reported to be activated by SM in the skin. Therefore, we h...
#1Shanji Liu (NCU: Nanchang University)H-Index: 3
#2Yu Zhao (NCU: Nanchang University)H-Index: 3
Last. Hengyi Xu (NCU: Nanchang University)H-Index: 33
view all 8 authors...
The wide application of TiO2 nanoparticles (NPs) and the increase in opportunities for its release into the environment undoubtedly compound the potential of these materials to harm people. Research on the effects of pre-exposure to TiO2-NPs on disease development is scarce. The purpose of this work was to assess whether pre-exposure to TiO2-NPs (20 mg/kg and 200 mg/kg) for 28 days aggravates the development of alcohol-related liver injury in mice. Results showed that oral administration of 200 ...
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