Original paper
Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation
Abstract
The plasticity of developing tissues relies on the adjustment of cell survival and growth rate to environmental cues. This includes the effect of mechanical cues on cell survival. Accordingly, compaction of an epithelium can lead to cell extrusion and cell death. This process was proposed to contribute to tissue homeostasis but also to facilitate the expansion of pretumoral cells through the compaction and elimination of the neighboring healthy...
Paper Details
Title
Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation
Published Date
Dec 13, 2018
Journal
Volume
29
Issue
1
Pages
23 - 34.e8