Behavioral responses of freshwater planarians have been studied for over a century.1 In recent decades, behavior has been used as a readout to study planarian development and regeneration,2-6 wound healing,7,8 molecular evolution,4,9,10 neurotoxicology,11-13 and learning and memory.14-17The planarian nervous system is among the simplest of the bilaterally symmetric animals,18 with an anterior brain attached to two ventral nerve cords interconnected by multiple commissures. We found that, in resp...
#2Nicholas Wilkerson(UPEI: University of Prince Edward Island)H-Index: 1
Last. Andrew Gordus(Johns Hopkins University)H-Index: 16
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Summary null null The geometric complexity and stereotypy of spider webs have long generated interest in their algorithmic origin. Like other examples of animal architecture, web construction is the result of several assembly phases that are driven by distinct behavioral stages coordinated to build a successful structure. Manual observations have revealed a range of sensory cues and movement patterns used during web construction, but methods to systematically quantify the dynamics of these senso...
Summary null null The early Drosophila embryo provides unique experimental advantages for addressing fundamental questions of gene regulation at multiple levels of organization, from individual gene loci to the entire genome. Using 1.5-h-old Drosophila embryos undergoing the first wave of genome activation, 1 null we detected ∼110 discrete “speckles” of RNA polymerase II (RNA Pol II) per nucleus, two of which were larger and localized to the histone locus bodies (HLBs). 2 , 3 null In the absence...
Nitrate, one of the main nitrogen (N) sources for crops, acts as a nutrient and key signaling molecule coordinating gene expression, metabolism, and various growth processes throughout the plant life cycle. It is widely accepted that nitrate-triggered developmental programs cooperate with hormone synthesis and transport to finely adapt plant architecture to N availability. Here, we report that nitrate, acting through its signaling pathway, promotes growth in Arabidopsis and wheat, in part by mod...
#1Prasad Vaddepalli(WUR: Wageningen University and Research Centre)H-Index: 8
#2Thijs de Zeeuw(WUR: Wageningen University and Research Centre)H-Index: 2
Last. Dolf Weijers(WUR: Wageningen University and Research Centre)H-Index: 56
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Summary null null Premitotic control of cell division orientation is critical for plant development, as cell walls prevent extensive cell remodeling or migration. While many divisions are proliferative and add cells to existing tissues, some divisions are formative and generate new tissue layers or growth axes. Such formative divisions are often asymmetric in nature, producing daughters with different fates. We have previously shown that, in the Arabidopsis thaliana embryo, developmental asymmet...
Summary null null The mushroom bodies of Drosophila contain circuitry compatible with race models of perceptual choice. When flies discriminate odor intensity differences, opponent pools of αβ core Kenyon cells (on and off αβc KCs) accumulate evidence for increases or decreases in odor concentration. These sensory neurons and “antineurons” connect to a layer of mushroom body output neurons (MBONs) which bias behavioral intent in opposite ways. All-to-all connectivity between the competing integr...
Summary null null In most tetrapod vertebrates, limb skeletal progenitors condense with postaxial dominance. Posterior elements (such as ulna and fibula) appear prior to their anterior counterparts (radius and tibia), followed by digit-appearance order with continuing postaxial polarity. The only exceptions are urodele amphibians (salamanders), whose limb elements develop with preaxial polarity and who are also notable for their unique ability to regenerate complete limbs as adults. The mechanis...
Summary null null The conspicuous warning signal of aposematic animals is learned by their predators, and the resulting avoidance benefits both parties. 1 , null 2 , null 3 , null 4 null Given evidence that birds can distinguish the profitability of prey from the environmental context in which they appear, 5 null aposematic insects’ host plants might also provide an important cue to foraging predators. 6 null The aposematic cinnabar moth (Tyria jacobaeae) larva is a specialist on its ragwort (Se...
Summary null null Actin-rich cellular protrusions direct versatile biological processes from cancer cell invasion to dendritic spine development. The stability, morphology, and specific biological functions of these protrusions are regulated by crosstalk between three main signaling axes: integrins, actin regulators, and small guanosine triphosphatases (GTPases). SHANK3 is a multifunctional scaffold protein, interacting with several actin-binding proteins and a well-established autism risk gene....
Last. Charan Ranganath(UC Davis: University of California, Davis)H-Index: 80
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Life's events are scattered throughout time, yet we often recall different events in the context of an integrated narrative. Prior research suggests that the hippocampus, which supports memory for past events, can support the integration of overlapping associations or separate events in memory. However, the conditions that lead to hippocampus-dependent memory integration are unclear. We used functional brain imaging to test whether the opportunity to form a larger narrative (narrative coherence)...