Original paper
Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion
Abstract
Ran is a nucleocytoplasmic shuttle protein that is involved in cell cycle regulation, nuclear-cytoplasmic transport, and cell transformation. Ran plays an important role in cancer cell survival and cancer progression. Here, we show that, in addition to the nucleocytoplasmic localization of Ran, this GTPase is specifically associated with the plasma membrane/ruffles of ovarian cancer cells. Ran depletion has a drastic effect on RhoA stability and...
Paper Details
Title
Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion
Published Date
Jun 17, 2019
Journal
Volume
10
Issue
1
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Notes
History