Breadth and depth of working memory and executive function compromises in mild cognitive impairment and their relationships to frontal lobe morphometry and functional competence

The extent of working memory (WM) and executive function (EF) impairment in mild cognitive impairment (MCI) is not well-characterized.We compared 48 patients with MCI, 124 noncognitively impaired elderly healthy controls, and 57 patients with Alzheimer's disease (AD) on multiple WM/EF measures, frontal lobe integrity indexes, and functioning.Patients with MCI demonstrated worse performance on nearly all WM/EF tests. This profile of impairment...