Autoimmune Pancreatitis Type 2: Diagnostic Utility of PD-L1 Immunohistochemistry.

Published on Jul 1, 2019in The American Journal of Surgical Pathology6.394
路 DOI :10.1097/PAS.0000000000001282
Rajib K Gupta7
Estimated H-index: 7
(State University of New York Upstate Medical University),
Azfar Neyaz10
Estimated H-index: 10
+ 6 AuthorsVikram Deshpande122
Estimated H-index: 122
Sources
Abstract
Background:Autoimmune pancreatitis (AIP) encompasses a heterogenous disease group that includes IgG4-related type 1 AIP and non鈥揑gG4-related type 2 AIP. Clinically and on imaging, type 2 AIP mimics type 1 AIP, other forms of chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC); therefore
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References13
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#1Xiaolong Liang (Peking Union Medical College Hospital)H-Index: 6
#2Jian Sun (Peking Union Medical College Hospital)H-Index: 53
Last. Tong-hua Liu (Peking Union Medical College Hospital)H-Index: 14
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Background Programmed death ligand 1 (PD-L1) has shown potential as a therapeutic target in numerous solid tumors. Its prognostic significance has also been established in pancreatic ductal adenocarcinoma (PDAC). The present study aimed to explore PD-L1 expression in PDAC cases in a large Chinese cohort using an in vitro diagnostic (IVD) assay to provide further insight into the potential value of programmed cell death protein 1 (PD-1) as a therapeutic target.
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#1Y. Ku (UOU: University of Ulsan)H-Index: 5
#2Seung-Mo HongH-Index: 60
Last. Yoh ZenH-Index: 89
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: Type 2 autoimmune pancreatitis (type 2 AIP) develops in isolation or sometimes in association with ulcerative colitis. Its diagnosis requires the histologic confirmation of granulocytic epithelial lesions (GELs) with no diagnostic biomarker currently available. This study aimed to elucidate the tissue expression of cytokines and their diagnostic value in this condition. In quantitative polymerase chain reaction for multiple cytokines using tissue-derived mRNA, the expression level of interleuk...
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#1Phil A. Hart (Mayo Clinic)H-Index: 29
#2Michael J. Levy (Mayo Clinic)H-Index: 108
Last. Suresh T. Chari (Mayo Clinic)H-Index: 103
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Objective Idiopathic duct-centric chronic pancreatitis (IDCP), also known as type 2 autoimmune pancreatitis (AIP), is an uncommon subtype of AIP. International Consensus Diagnostic Criteria for IDCP propose that the diagnosis requires pancreatic histology and/or concurrent IBD. We examined our experience with IDCP (type 2 AIP) to assess the appropriateness of these criteria, and identify unique characteristics in patients presenting with acute pancreatitis. Design We reviewed the Mayo Clinic AIP...
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#1Lik Hang Lee (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 8
#2Marcela S. Cavalcanti (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 5
Last. Jinru Shia (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 95
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Immune checkpoint blockade targeting the programmed death-1 (PD-1) pathway has shown efficacy in several types of cancers including mismatch-repair-deficient colorectal carcinoma. In some tumor types, programmed death-ligand 1 (PD-L1) expression detected by immunohistochemistry has shown utility as a predictive marker for response to anti-PD-1 therapies. This utility, however, remains to be determined in colorectal carcinoma. In addition, although tumor-infiltrating lymphocytes have been associa...
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#1Nicolas J. Llosa (Johns Hopkins University)H-Index: 13
#2Michael Cruise (Johns Hopkins University)H-Index: 13
Last. Franck Housseau (Johns Hopkins University)H-Index: 37
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We examined the immune microenvironment of primary colorectal cancer using immunohistochemistry, laser capture microdissection/qRT-PCR, flow cytometry, and functional analysis of tumor-infiltrating lymphocytes. A subset of colorectal cancer displayed high infiltration with activated CD8+ cytotoxic T lymphocyte (CTL) as well as activated Th1 cells characterized by IFN纬 production and the Th1 transcription factor TBET. Parallel analysis of tumor genotypes revealed that virtually all of the tumors ...
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#1S枚nke Detlefsen (OUH: Odense University Hospital)H-Index: 23
#2Giuseppe Zamboni (University of Verona)H-Index: 82
Last. G眉nter Kl枚ppel (TUM: Technische Universit盲t M眉nchen)H-Index: 54
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Abstract Background At the recent consensus conference on autoimmune pancreatitis (AIP) in Honolulu, we presented preliminary data from our study of surgically treated AIP patients. Our data strongly supported the separation of AIP into type 1 and type 2. Our study is based on a total of 114 surgically treated European AIP patients. Our aims were to elucidate serum IgG4 elevation, other organ involvement, relapse of disease, steroid treatment and diabetes after surgery in 114 surgically treated ...
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#1Terumi Kamisawa (Tokyo Metropolitan Komagome Hospital)H-Index: 77
#2Suresh T. ChariH-Index: 103
Last. Vay Liang W. Go (UCLA: University of California, Los Angeles)H-Index: 94
view all 22 authors...
: The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world.: An international multicenter survey of AIP was conducted in 15 institutes from 8 countries. We compared clinical and pathologic profiles of AIP (n = 731) and the clinical profiles of LPSP (n = 204) and IDCP (n = 64) patients.: Pat...
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#1Tooru Shimosegawa (Tohoku University)H-Index: 94
#2Suresh T. ChariH-Index: 103
Last. Lizhi ZhangH-Index: 51
view all 14 authors...
Objectives:To achieve the goal of developing international consensus diagnostic criteria (ICDC) for autoimmune pancreatitis (AIP).Methods:An international panel of experts met during the 14th Congress of the International Association of Pancreatology held in Fukuoka, Japan, from July 11 through 13,
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#1Raghuwansh P. Sah (Mayo Clinic)H-Index: 18
#2Suresh T. Chari (Mayo Clinic)H-Index: 103
Last. Santhi Swaroop Vege (Mayo Clinic)H-Index: 52
view all 13 authors...
Background & Aims Autoimmune pancreatitis (AIP) has been divided into subtypes 1 (lymphoplasmacytic sclerosing pancreatitis) and 2 (idiopathic duct centric pancreatitis). We compared clinical profiles and long-term outcomes of types 1 and 2 AIP. Methods We compared clinical presentation, relapse, and vital status of 78 patients with type 1 AIP who met the original HISORt criteria and 19 patients with histologically confirmed type 2 AIP. Results At presentation, patients with type 1 AIP were olde...
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Cited By6
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Autoimmune pancreatitis (AIP) is characterized by a tumefactive inflammatory lesion resembling pancreatic carcinoma. Type 1 AIP is a pancreatic manifestation of IgG4-related disease characterized by unique histological features that can be identified on imaging. The capsule-like rim, which is a collar of hypertrophic lesion surrounding the pancreas, consists of lymphoplasmacytic infiltration and fibrosis, and storiform fibrosis is often identified. Hypertrophic lesions of various microscopic arc...
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#1Anna Krupa (UMB: Medical University of Bia艂ystok)H-Index: 1
#2Irina Kowalska (UMB: Medical University of Bia艂ystok)H-Index: 48
The kynurenine pathway (KP) is highly regulated in the immune system, where it promotes immunosuppression in response to infection or inflammation. Indoleamine 2,3-dioxygenase 1 (IDO1), the main enzyme of KP, has a broad spectrum of activity on immune cells regulation, controlling the balance between stimulation and suppression of the immune system at sites of local inflammation, relevant to a wide range of autoimmune and inflammatory diseases. Various autoimmune diseases, among them endocrinopa...
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#1S枚nke Detlefsen (University of Southern Denmark)H-Index: 23
#2S酶ren Schou Olesen (AAU: Aalborg University)H-Index: 30
Abstract Autoimmune pancreatitis (AIP) is a distinct form of chronic pancreatitis that has been increasingly recognised over the last decades and shows a good response to corticosteroid treatment. Two different forms of AIP have been characterized. Type 1 AIP is the pancreatic manifestation of IgG4-related disease and often affects multiple organ systems. In contrast, type 2 AIP is confined to the pancreas and involvement of extra-pancreatic organs has previously only very rarely been reported, ...
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#1Clarissa A. Cassol (OSU: Ohio State University)H-Index: 11
#2Dwight H. Owen (OSU: Ohio State University)H-Index: 14
Last. Christina A. Arnold (OSU: Ohio State University)H-Index: 21
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AIMS: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced malignancies by boosting immune-mediated destruction of neoplastic cells, but course with side effects stemming from generalized immune system activation against normal tissues. Checkpoint ligand expression in non-tumoral cells of tissues affected by immune-related adverse effects has been described in ICI-associated hypophysitis, myocarditis, and acute interstitial nephritis. We aimed to investigate the tiss...
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#1Gitte Hedegaard Jensen (OUH: Odense University Hospital)H-Index: 1
#2Michael Bau Mortensen (University of Southern Denmark)H-Index: 21
Last. S枚nke Detlefsen (University of Southern Denmark)H-Index: 23
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Abstract Morphology plays an important role in the distinction of autoimmune pancreatitis (AIP) from pancreatic ductal adenocarcinoma (PDAC). However, we aimed to determine the utility of immunohistochemical tumor markers to contribute in the distinction of these entities. In surgical specimens with AIP (n鈥=鈥20), PDAC (n鈥=鈥20) and normal pancreas (n鈥=鈥20), the expression of pVHL, maspin, IMP3, S100鈥塒 and Ki67 was examined. We evaluated intralobular reactive ducts / acinoductal metaplasia (ILDs) ...
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Context.鈥 The separation of benign from malignant mesothelial proliferations is a difficult morphologic problem. Some mesotheliomas stain for programmed death ligand-1 (PD-L1). Objective.鈥 To deter...
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