Studies of novel bioprobes isolated from rare natural sources using mutant yeasts

For the discovery of novel drug candidates and bioprobes, it is important to investigate rare natural sources with unique screening methods. Our group tested 1000 original MeOH extracts from natural sources, such as plants and food ingredients using six types of mutant yeasts. In our experiments, Kuji amber was used as the rare domestic natural source and the growth-restoring activity (positive screening) of mutant yeast involving Ca2+-signal...