The Journal of Antibiotics
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#1Enjuro Harunari (Toyama Prefectural University)H-Index: 9
#2Maho Bando (Toyama Prefectural University)H-Index: 1
Last. Yasuhiro Igarashi (Toyama Prefectural University)H-Index: 31
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A new pluramycin-class polyketide, rausuquinone (1), and its known congener hydramycin (2) were isolated from the culture extract of the deep-sea water-derived Rhodococcus sp. RD015140. Compound 1 possesses a γ-pyrone-fused anthraquinone core with a 3-butene-1,2-diol side chain. Structures of 1 was determined by extensive analysis of 1D and 2D NMR spectroscopic data. Compound 1 showed antimicrobial activity against Gram-positive bacteria. This is the first discovery of aromatic polyketides from ...
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#1Kohei Ishida (Kindai University)
#2Teruki Tanaka (Kindai University)
Last. Takashi Fukuda (Kindai University)H-Index: 2
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Seriniquinone was originally isolated as a melanoma-selective anti-cancer agent from a culture broth of marine bacteria. Pharmacological studies on its selectivity and unique target are ongoing. A new dihydronaphthothiophene (1) was synthesized by the biological transformation of seriniquinone using marine-derived actinomycete Streptomyces albogriseolus OM27-12, and its derivatives (2-4) were chemically synthesized. Compounds 1-4 exhibited selective cytotoxic activity against melanoma and improv...
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#1Xueying Xie (Qilu University of Technology)
#2Zexi Zhao (CAS: Chinese Academy of Sciences)
Last. Yan Bai (CAS: Chinese Academy of Sciences)H-Index: 1
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A new compound classified as one new azaphilone derivative, nigirpexin E (1), was obtained from the soil-derived fungus Trichoderma afroharzianum LTR-2, together with seven known compounds (2-8). The structures of 1-8 were determined by their HRESIMS, optical rotation, and NMR spectroscopic data. The absolute configuration of nigirpexin E (1) was determined on the basis of comparisons of experimental and theoretically calculated ECD spectra. Compound 3 was firstly isolated from Trichoderma. Bioa...
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#1Kiyoko Fujita (Taisho Pharmaceutical Co.)H-Index: 3
#2Iichiro Takata (Taisho Pharmaceutical Co.)H-Index: 3
Last. Hiroyuki Sugiyama (Taisho Pharmaceutical Co.)H-Index: 5
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The emergence of multi-drug resistant pathogenic bacteria, especially Gram-negative bacteria, is a worldwide health problem. New antibiotics directed at previously unexplored targets are urgently needed to overcome resistance to existing antibiotic classes. UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is an attractive target for a new antibacterial agent. Although a number of LpxC inhibitors have been identified, none have been approved as antibacterial agents. These LpxC inhibitors conta...
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#1Yuta Ibusuki (Tokyo University of Science)H-Index: 1
#2Shoko Kimata (Tokyo University of Science)H-Index: 3
Last. Yoichi Hayakawa (Tokyo University of Science)H-Index: 21
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A neuroprotective compound (2) was isolated from the culture broth of the dutomycin (1) producer Streptomyces sp. RAP78. The molecular formula of 2 was established as C44H55NO16 by high-resolution FAB-MS. The structure was determined to be a new dutomycin derivative possessing an acetimidoyl group in place of an acetyl group by NMR spectroscopic analysis. 13-Deoxo-13-iminodutomycin (2) but not dutomycin (1) protected C6 rat glioma cells and N18-RE-105 rat primary retina-mouse neuroblastoma hybri...
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#1Hui Zhang (NEAU: Northeast Agricultural University)H-Index: 1
#2Huan QiH-Index: 5
Last. Wensheng Xiang (NEAU: Northeast Agricultural University)H-Index: 20
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A double disulfide tethering depsipeptide dimer, romipeptide A (1) was prepared by NaOH catalyzed dimerization of romidepsin. Its structure was determined by analysis of NMR and HR-ESI-MS data as well as single crystal X-ray diffraction. Bioassay results showed that 1 exhibited good cytotoxic activity against two tumor cell lines B16 and HCT116. This study reported the single crystal data of 1 for the first time. The facile preparation of 1 afforded enough amount for its further biological evalu...
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#1Tomohiro Kagi (Tohoku University)H-Index: 2
#2Rio Naganuma (Tohoku University)H-Index: 1
Last. Atsushi Matsuzawa (Tohoku University)H-Index: 45
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Polymyxin B (PMB) is an essential antibiotic active against multidrug-resistant bacteria, such as multidrug-resistant Pseudomonas aeruginosa (MDRP). However, the clinical use of PMB is limited, because PMB causes serious side effects, such as nephrotoxicity and neurotoxicity, probably due to its cytotoxic activity. However, cytotoxic mechanisms of PMB are poorly understood. In this study, we found that macrophages are particularly sensitive to PMB, when compared with other types of cells, includ...
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#1Hitoshi Kamauchi (Josai University)H-Index: 3
#2Mitsuaki Suzuki (Josai University)H-Index: 18
Last. Yoshiaki Sugita (Josai University)H-Index: 17
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The ribosome-targeted antifungal agent hygromycin B (HygB) alters the secondary metabolite profiles of fungi. Hypoxylon truncatum NBRC 32353 fermented in the presence of hygromycin B in barley medium activated secondary metabolite synthesis. A new benzaldehyde derivative truncaaldehyde (1) was obtained, along with thirteen known compounds (2-14). The structures of the new compounds were revealed using NMR and single-crystal X-ray crystallography. The total synthesis of (±)-1 was achieved using a...
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#1Marhaba Ahmat (CAU: China Agricultural University)
#2Junhao Cheng (CAU: China Agricultural University)H-Index: 3
Last. Rijun Zhang (CAU: China Agricultural University)H-Index: 10
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This study aimed to investigate the effects of Bacillus amyloliquefaciens LFB112 on the growth performance, carcass traits, immune response, and serum biochemical parameters of broiler chickens. A total of 396 1 day old, mixed-sex commercial Ross 308 broilers with similar body weights were allotted into six treatment groups. The assigned groups were the CON group (basal diet with no supplement), AB (antibiotics) group (basal diet + 150 mg of aureomycin/kg), C+M group (basal diet + 5 × 108 CFU/kg...
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#1Atsushi Uda (Kobe University)H-Index: 7
#2Katsumi Shigemura (Kobe University)H-Index: 23
Last. Takayuki Miyara (Kobe University)H-Index: 4
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Since 2014, several global and national guidelines have been introduced to address the problem of antimicrobial resistance. We conducted a campaign in a tertiary hospital to promote appropriate quinolone use through educational lectures in 2018. The aim of this retrospective study was to evaluate the changes in the following: prescription characteristics, trend of oral quinolone use, and antibiotic susceptibility of bacteria from 2013 to 2020. Antimicrobial use was assessed as days of therapy pe...
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