Original paper
Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production
Abstract
Neuromyelitis optica spectrum disorders (NMOSD) constitute rare autoimmune disorders of the CNS that are primarily characterized by severe inflammation of the spinal cord and optic nerve. Approximately 75% of NMOSD patients harbour circulating pathogenic autoantibodies targeting the aquaporin-4 water channel (AQP4). The source of these autoantibodies remains unclear, but parallels between NMOSD and other autoantibody-mediated diseases posit...
Paper Details
Title
Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production
Published Date
May 5, 2019
Journal
Volume
142
Issue
6
Pages
1598 - 1615
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Notes
History