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#1Kanta HorieH-Index: 13
Last. Randall J. BatemanH-Index: 61
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#1Michael J Hurley (University of Southampton)H-Index: 1
#2Robert M.J. DeaconH-Index: 6
Last. Patricia Cogram (University of Chile)H-Index: 13
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Fragile X Syndrome is the most common inherited intellectual disability and mono-genetic cause of autism spectrum disorder. It is a neurodevelopmental condition occurring due to a CGG trinucleotide expansion in the FMR1 gene. Polymorphisms and variants in large-conductance calcium-activated potassium channels are increasingly linked to intellectual disability and loss of FMR protein caused reduced large-conductance calcium-activated potassium channel activity leading to abnormalities in synapse ...
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#1Nadine Attal (UVSQ: Versailles Saint-Quentin-en-Yvelines University)H-Index: 60
#2Frédérique Poindessous-Jazat (French Institute of Health and Medical Research)H-Index: 12
Last. Jean-Pascal Lefaucheur (Paris 12 Val de Marne University)H-Index: 8
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Repetitive transcranial magnetic stimulation (rTMS) has been proposed to treat neuropathic pain but the quality of evidence remains low. We aimed to assess the efficacy and safety of neuronavigated rTMS to the motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) in neuropathic pain over 25 weeks. We did a randomised double-blind, placebo-controlled trial at four outpatient clinics in France. Patients aged 18-75 years with peripheral neuropathic pain were randomly assigned in a 1:1 ratio t...
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#1Xiaojie Zhao (RFUMS: Rosalind Franklin University of Medicine and Science)H-Index: 1
#2Kelly Wilson (RFUMS: Rosalind Franklin University of Medicine and Science)
Last. Johnny J He (RFUMS: Rosalind Franklin University of Medicine and Science)H-Index: 1
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HIV-associated neurocognitive disorders (HAND) in the era of combination antiretroviral therapy are primarily manifested as impaired behaviors, glial activation/neuroinflammation and compromised neuronal integrity, for which there are no effective treatments currently available. In the current study, we used doxycycline-inducible astrocyte-specific HIV Tat transgenic mice (iTat), a surrogate HAND model and determined effects of PNU-125096, a positive allosteric modulator of α7 nicotinic acetylch...
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#1Christopher E J Doppler (University of Cologne)H-Index: 1
#2Martin B. Kinnerup (Aarhus University Hospital)H-Index: 4
Last. Aline D. Seger (University of Cologne)H-Index: 1
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Previous studies have reported substantial involvement of the noradrenergic system in Parkinson's disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and the density of noradrenergic terminal transporters. Combining these methods, we investigated the relationship of neurodegeneration in these distinct compartments in Parkinson's disease. We examined 93 subjects (40 healthy controls and 53 Parkinson's disease pati...
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#1Stefan Bittner (University of Mainz)H-Index: 33
#2Jiwon Oh (U of T: University of Toronto)H-Index: 27
Last. Frauke Zipp (University of Mainz)H-Index: 79
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Multiple sclerosis is a highly heterogeneous disease and the detection of neuroaxonal damage as well as its quantification is a critical step for patients. Blood-based neurofilament light chain (sNfL) is currently under close investigation as an easily accessible biomarker of prognosis and treatment response for multiple sclerosis patients. There is abundant evidence that sNfL levels reflect ongoing inflammatory-driven neuroaxonal damage (e.g. relapses or MRI disease activity) and that sNfL leve...
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#1Michael ZechH-Index: 12
#2Annette Seibt (HHU: University of Düsseldorf)H-Index: 15
Last. Felix Distelmaier (HHU: University of Düsseldorf)H-Index: 33
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#1Federica InvernizziH-Index: 31
#2Andrea LegatiH-Index: 16
Last. Costanza LampertiH-Index: 38
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#1Peggy Seriès (Edin.: University of Edinburgh)H-Index: 23
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