MON-485 Effects of Orexin A on Prolactin Production by Regulating BMP-4 Activity in Rat Pituitary Lactotorope Cells

Orexin A and B, are neuropeptides that are mainly produced in the hypothalamus. Orexins play important roles in food intake and in regulation of sleep and arousal. In the peripheral tissues, orexins also regulate various endocrine activities including the hypothalamic-pituitary-adrenal and -gonadal axes and growth hormone control. However, the effects of orexin on prolactin synthesis have not been clarified. Here, we focused on the role of bone...