Depression, Antidepressants, and Inflammatory Bowel Disease: Implications for Future Models of Care

Frolkis AD, Vallerand IA, Shaheen A-A, et al. Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression. Gut 2018;doi:10.1136/gutjnl-2018-317182 The etiology of inflammatory bowel disease (IBD) is uncertain, but may arise as a consequence of an abnormal immune response to a proinflammatory microbiome, in genetically susceptible individuals. Modifiable risk...