Alexander C. Ford
University of Leeds
Internal medicineSurgeryOdds ratioRandomized controlled trialIntensive care medicinePlaceboHelicobacter pyloriInflammatory bowel diseaseIrritable bowel syndromeDiseaseCrohn's diseaseMEDLINEUlcerative colitisConstipationPopulationConfidence intervalMedicineRelative riskGastroenterologyMeta-analysis
554Publications
86H-index
18.2kCitations
Publications 548
Newest
#1Nuno Ferreira (University of Nicosia)H-Index: 12
#2Antonina Mikocka-Walus (Deakin University)H-Index: 29
Last. Megan L. Petrik (UMN: University of Minnesota)H-Index: 7
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Abstract null null Objective null The COVID-19 pandemic has had a significant impact on mental health across the globe. People living with a chronic gastrointestinal (GI) disorder might be particularly at risk of mental health complications given higher rates of comorbid anxiety and depression compared to the healthy population. As GI disorders affect up to 40% of the population worldwide, this international collaborative study seeks to evaluate the extent of the impact of the COVID-19 pandemic ...
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#1Alfred D. Nelson (Mayo Clinic)H-Index: 10
#2Christopher J Black (St James's University Hospital)H-Index: 13
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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#1Keeley M. Fairbrass (University of Leeds)H-Index: 2
#2David J. Gracie (University of Leeds)H-Index: 16
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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BACKGROUND Psychological co-morbidity is more common in patients with inflammatory bowel disease (IBD), compared with the general population, but little is known about the cumulative effect of increasing psychological burden on disease behaviour. AIMS To examine the effect of psychological co-morbidity on inflammatory bowel disease in a longitudinal follow-up study. METHODS We collected complete demographic, symptom and psychological co-morbidity data (anxiety, depression and somatisation scores...
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#1Alfred D. Nelson (Mayo Clinic)H-Index: 10
#2Christopher J Black (St James's University Hospital)H-Index: 13
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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BACKGROUND Although bloating is a highly prevalent and troublesome symptom in irritable bowel syndrome with constipation (IBS-C), treatment is empirical with no specific guidelines for its management. AIM To conduct a pairwise and network meta-analysis, using a frequentist approach, of Food and Drug Administration-licensed drugs for IBS-C comparing their efficacy for abdominal bloating as a specific endpoint. METHODS We searched the medical literature through December 2020 to identify randomised...
2 CitationsSource
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Ciaran Judge (St James's University Hospital)H-Index: 1
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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Summary null Background null Functional constipation is a common functional bowel disorder in the community, which has a varying prevalence across cross-sectional surveys. We did a contemporaneous systematic review and meta-analysis of studies using comparable methodology and all iterations of the Rome criteria to estimate the global prevalence of functional constipation. null Methods null In this systematic review and meta-analysis, we searched MEDLINE, Embase, and Embase Classic from Jan 1, 19...
1 CitationsSource
#1Christopher J BlackH-Index: 13
#2Orla Craig (Leeds Teaching Hospitals NHS Trust)H-Index: 1
Last. Alexander C. FordH-Index: 86
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Objectives Despite being proposed 4 years ago, there has been no independent validation study of the Rome IV criteria for IBS. We assessed their performance for the diagnosis of IBS in secondary care and compared them with the previous iteration, the Rome III criteria. Design We collected complete symptom data from consecutive adult patients with suspected IBS referred to a single UK clinic. All subjects underwent relatively standardised workup, with assessors blinded to symptom status. The refe...
2 CitationsSource
#1Brigida Barberio (UNIPD: University of Padua)H-Index: 7
#2Christopher J Black (University of Leeds)H-Index: 13
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 4 authors...
BACKGROUND Despite randomized controlled trials [RCTs] and trial-based meta-analyses, the optimal rescue therapy for patients with acute glucorticosteroid-refractory ulcerative colitis [UC], to avoid colectomy and improve long-term outcomes, remains unclear. We conducted a network meta-analysis examining this issue. METHODS We searched MEDLINE, EMBASE, EMBASE Classic and the Cochrane central register up to June 2020. We included RCTs comparing ciclosporin and infliximab, either with each other o...
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#1Vivek C. Goodoory (University of Leeds)
#2Lesley A. Houghton (University of Leeds)H-Index: 53
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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ABSTRACT Objectives Irritable bowel syndrome (IBS) is a chronic functional bowel disorder diagnosed using the Rome criteria, which have evolved since their original description 30 years ago. Little is known about the effects on the natural history of IBS of moving to the latest iteration, Rome IV, from the previous Rome III criteria. We conducted a 12-month longitudinal follow-up study examining this. Methods We collected complete demographic, symptom, mood, and psychological health data at base...
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#1Tim Klaassen (Maastricht University Medical Centre)H-Index: 3
#2Fabiënne G M Smeets (Maastricht University Medical Centre)H-Index: 5
Last. Daniel Keszthelyi (Maastricht University Medical Centre)H-Index: 28
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BACKGROUND Due to important biases, conventional end-of-day and end-of-week assessment methods of gastrointestinal symptoms in functional dyspepsia (FD) are considered suboptimal. Real-time symptom assessment based on the experience sampling method (ESM) could be a more accurate measurement method. This study aimed to evaluate validity and reliability of an ESM-based patient-reported outcome measure (PROM) for symptom assessment in FD. METHODS Thirty-five patients with FD (25 female, mean age 44...
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#1Christopher J Black (University of Leeds)H-Index: 13
#2Alexander C. Ford (University of Leeds)H-Index: 86
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