Original paper
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
Abstract
L-amino acid transporters (LATs) play key roles in human physiology and are implicated in several human pathologies. LATs are asymmetric amino acid exchangers where the low apparent affinity cytoplasmic side controls the exchange of substrates with high apparent affinity on the extracellular side. Here, we report the crystal structures of an LAT, the bacterial alanine-serine-cysteine exchanger (BasC), in a non-occluded inward-facing conformation...
Paper Details
Title
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
Published Date
Apr 18, 2019
Journal
Volume
10
Issue
1